酸性高锰酸钾-亚硫酸盐体系流动注射化学发光法测定洛索洛芬和萘普生
Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system.
作者信息
Wang Li-Juan, Tang Yu-Hai, Liu Yang-Hao
机构信息
Medical School, Xi'an Jiaotong University, Xi'an 710061, China.
Institute of Analytical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
出版信息
J Pharm Anal. 2011 Feb;1(1):51-56. doi: 10.1016/S2095-1779(11)70009-0. Epub 2012 Jan 30.
A novel flow injection chemiluminescence (CL) method for the determination of loxoprofen and naproxen was proposed based on the CL system of KMnO, and NaSO in acid media. The CL intensity of KMnO-NaSO was greatly enhaneed in the presence of loxoprofen and naproxen. The mechanism of the CL reaction was studied by the kinetic proecss and UV-vis absorption and the conditions were optimized. Under optimized conditions, the CL intensity was linear with loxoprofen and naproxen concentration in the range of 7.0 × 10 - 1.0 × 10 g/mL and 2.0 × 10 - 4.0 × 10 g/mL with the detection limit of 2.0 × 10 g/mL and 3.0 × 10 g/mL (S/N = 3), respectively. Thc relative standard deviations were 2.39% and 1.37% for 5.0 × 10 g/mL naproxen and 5.0 × 10 g/mL loxoprofen ( = 10), respectively. The proposed method was satisfactorily applied to thc determination of loxoprofen and naproxen in pharmaceutical preparations.
基于酸性介质中高锰酸钾和亚硫酸钠的化学发光（CL）体系，提出了一种测定洛索洛芬和萘普生的新型流动注射化学发光法。在洛索洛芬和萘普生存在下，高锰酸钾-亚硫酸钠的化学发光强度大大增强。通过动力学过程、紫外可见吸收对化学发光反应机理进行了研究，并对条件进行了优化。在优化条件下，化学发光强度与洛索洛芬和萘普生浓度在7.0×10⁻⁷ - 1.0×10⁻⁵ g/mL和2.0×10⁻⁶ - 4.0×10⁻⁵ g/mL范围内呈线性关系，检测限分别为2.0×10⁻⁷ g/mL和3.0×10⁻⁷ g/mL（S/N = 3）。对于5.0×10⁻⁶ g/mL萘普生和5.0×10⁻⁶ g/mL洛索洛芬（n = 10），相对标准偏差分别为2.39%和1.37%。该方法成功应用于药物制剂中洛索洛芬和萘普生的测定。
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