Atolani Olubunmi, Olatunji Gabriel A
Department of Chemical Sciences, Redeemer׳s University, P.M.B. 3005, Redemption Camp, Mowe, Ogun State, Nigeria.
Department of Chemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria.
J Pharm Anal. 2014 Dec;4(6):407-411. doi: 10.1016/j.jpha.2014.05.002. Epub 2014 May 20.
A furano-diterpene (polyalthic acid) was isolated as a major stable compound for the first time from the oleoresin of the of the family Caesalpiniacea through column chromatography fractionation. Polyalthic acid was characterized using data obtained from EIMS, HREIMS, ESI-MS, MALDI-MS as well as 1D and 2D NMR and it was evaluated for its potential to inhibit the formation of advanced glycation end-products (AGEs) using a standard antiglycation procedure. Polyalthic acid indicated a negative antiglycation potential compared to standard inhibitor that has 85% inhibition, which is an indication that polyalthic acid may not contribute to the antiglycation activity of the plant as acclaimed in folkloric medicine. The negative antiglycation observed could indicate that the polyalthic acid could trigger glycation, thereby subjecting users to various degrees of complications. The bioactivity evaluation on molinspiration evaluator indicated that polyalthic acid could be a potential drug candidate. The biological and chemical insights gained on polyalthic acid provide a good basis for future research.
首次通过柱色谱分离从豆科植物的油树脂中分离出一种呋喃二萜（多花酸）作为主要稳定化合物。利用电子轰击质谱（EIMS）、高分辨电子轰击质谱（HREIMS）、电喷雾电离质谱（ESI-MS）、基质辅助激光解吸电离质谱（MALDI-MS）以及一维和二维核磁共振（1D和2D NMR）获得的数据对多花酸进行了表征，并采用标准抗糖化程序评估了其抑制晚期糖基化终产物（AGEs）形成的潜力。与具有85%抑制率的标准抑制剂相比，多花酸显示出负抗糖化潜力，这表明多花酸可能不像民间医学所宣称的那样对该植物的抗糖化活性有贡献。观察到的负抗糖化作用可能表明多花酸会引发糖基化，从而使使用者面临各种程度的并发症。在molinspiration评估器上进行的生物活性评估表明，多花酸可能是一种潜在的候选药物。对多花酸获得的生物学和化学见解为未来的研究提供了良好的基础。
