肿瘤内细菌可能通过代谢抗癌药物引发化疗耐药。
Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents.
作者信息
Geller Leore T, Straussman Ravid
机构信息
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
出版信息
Mol Cell Oncol. 2017 Dec 11;5(1):e1405139. doi: 10.1080/23723556.2017.1405139. eCollection 2018.
Abstract
We recently reported that bacteria can be found within pancreatic ductal adenocarcinoma (PDAC) tumors. Some of these bacteria can metabolize and thereby inactivate the nucleoside analog gemcitabine. We demonstrated that the long isoform of the bacterial enzyme cytidine deaminase (CDD) mediates the metabolism of gemcitabine. The clinical effect of overcoming this potential mechanism of drug resistance has yet to be studied.
摘要
我们最近报道，在胰腺导管腺癌（PDAC）肿瘤中可以发现细菌。其中一些细菌能够代谢核苷类似物吉西他滨并使其失活。我们证明细菌胞苷脱氨酶（CDD）的长异构体介导了吉西他滨的代谢。克服这种潜在耐药机制的临床效果尚未得到研究。
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