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Targeting bile acids and lipotoxicity for NASH treatment.

作者信息

Chiang John Y L

机构信息

Northeast Ohio Medical University Rootstown OH.

出版信息

Hepatol Commun. 2017 Dec 4;1(10):1002-1004. doi: 10.1002/hep4.1127. eCollection 2017 Dec.

DOI:10.1002/hep4.1127
PMID:29404437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5721403/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50e5/5721403/5ebb022d5def/HEP4-1-1002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50e5/5721403/5ebb022d5def/HEP4-1-1002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50e5/5721403/5ebb022d5def/HEP4-1-1002-g001.jpg

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An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.肠道法尼醇X受体-神经酰胺信号轴调节小鼠肝脏糖异生
Diabetes. 2017 Mar;66(3):613-626. doi: 10.2337/db16-0663. Epub 2016 Nov 8.
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A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.
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Int J Mol Sci. 2023 Sep 12;24(18):13997. doi: 10.3390/ijms241813997.
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FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models.FASN 抑制通过减少临床前模型中的脂肪变性、炎症和纤维化来靶向 NASH 的多种驱动因素。
Sci Rep. 2022 Sep 19;12(1):15661. doi: 10.1038/s41598-022-19459-z.
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