由结晶蛋白质基质构建的超分子蛋白质笼。
Supramolecular protein cages constructed from a crystalline protein matrix.
作者信息
Negishi Hashiru, Abe Satoshi, Yamashita Keitaro, Hirata Kunio, Niwase Kento, Boudes Marion, Coulibaly Fasséli, Mori Hajime, Ueno Takafumi
机构信息
School of Life Science and Technology, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
出版信息
Chem Commun (Camb). 2018 Feb 20;54(16):1988-1991. doi: 10.1039/c7cc08689j.
Protein crystals are formed via ordered arrangements of proteins, which assemble to form supramolecular structures. Here, we show a method for the assembly of supramolecular protein cages within a crystalline environment. The cages are stabilized by covalent cross-linking allowing their release via dissolution of the crystal. The high stability of the desiccated protein crystals allows cages to be constructed.
蛋白质晶体通过蛋白质的有序排列形成，这些蛋白质组装形成超分子结构。在这里，我们展示了一种在晶体环境中组装超分子蛋白质笼的方法。这些笼子通过共价交联得以稳定，从而可以通过晶体溶解实现释放。干燥的蛋白质晶体的高稳定性使得能够构建笼子。
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