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通过近红外光谱法测量小儿抽动秽语综合征中的前额叶功能障碍。

Prefrontal dysfunction in pediatric Tourette's disorder as measured by near-infrared spectroscopy.

作者信息

Yamamuro Kazuhiko, Ota Toyosaku, Iida Junzo, Nakanishi Yoko, Uratani Mitsuhiro, Matsuura Hiroki, Kishimoto Naoko, Tanaka Shohei, Negoro Hideki, Kishimoto Toshifumi

机构信息

Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijyou-cho, Kashihara, Nara, 634-8522, Japan.

Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Nara, Japan.

出版信息

BMC Psychiatry. 2015 May 3;15:102. doi: 10.1186/s12888-015-0472-3.

DOI:10.1186/s12888-015-0472-3
PMID:25934008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4422308/
Abstract

BACKGROUND

Tourette's disorder (TD) is a chronic childhood-onset disorder characterized by the presence of multiple motor and vocal tics. Despite strong evidence that the pathophysiology of TD involves structural and functional disturbances of the basal ganglia and cortical frontal areas, in vivo imaging studies have produced conflicting results. Recent developments in near-infrared spectroscopy (NIRS) technology have enabled noninvasive assessment of brain function in people with psychiatric disorders.

METHODS

We asked 10 individuals with pediatric TD and 10 healthy controls who were age- and sex- matched to perform the Stroop color-word task during NIRS. We used prefrontal probes and a 24-channel NIRS machine to measure the relative concentrations of oxyhemoglobin (oxy-Hb) every 0.1 s during the task.

RESULTS

We found that oxy-Hb changes in the prefrontal cortex were significantly smaller in the TD group compared with the control group, especially in the left dorsolateral prefrontal cortex.

CONCLUSIONS

Our data suggest that individuals with pediatric TD have a reduced prefrontal hemodynamic response as measured by NIRS.

摘要

背景

图雷特氏障碍（TD）是一种始于儿童期的慢性疾病，其特征为存在多种运动性和发声性抽动。尽管有充分证据表明TD的病理生理学涉及基底神经节和额叶皮质的结构与功能紊乱，但活体成像研究结果却相互矛盾。近红外光谱（NIRS）技术的最新进展使得对精神疾病患者的脑功能进行无创评估成为可能。

方法

我们让10名患有儿童TD的个体和10名年龄及性别匹配的健康对照者在进行NIRS检查时执行斯特鲁普颜色-文字任务。我们使用前额叶探头和一台24通道NIRS机器在任务过程中每隔0.1秒测量一次氧合血红蛋白（oxy-Hb）的相对浓度。

结果

我们发现，与对照组相比，TD组前额叶皮质中的oxy-Hb变化明显更小，尤其是在左侧背外侧前额叶皮质。

结论

我们的数据表明，通过NIRS测量，患有儿童TD的个体前额叶血流动力学反应降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afea/4422308/35910a011644/12888_2015_472_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afea/4422308/27c488d22759/12888_2015_472_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afea/4422308/1e14dbc5bc52/12888_2015_472_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afea/4422308/35910a011644/12888_2015_472_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afea/4422308/27c488d22759/12888_2015_472_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afea/4422308/1e14dbc5bc52/12888_2015_472_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afea/4422308/35910a011644/12888_2015_472_Fig3_HTML.jpg

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2
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3
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J Neurodev Disord. 2023 Oct 25;15(1):34. doi: 10.1186/s11689-023-09501-0.
4
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5
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6
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CNS Neurosci Ther. 2018 Oct;24(10):863-875. doi: 10.1111/cns.13036. Epub 2018 Jul 24.
7
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7
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10
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