中性粒细胞与淋巴细胞比值对口腔鳞状细胞癌预后价值的荟萃分析。
Meta-analysis of the prognostic value of the neutrophil-to-lymphocyte ratio in oral squamous cell carcinoma.
机构信息
Department of Periodontology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
出版信息
J Oral Pathol Med. 2018 Apr;47(4):353-358. doi: 10.1111/jop.12688. Epub 2018 Mar 2.
BACKGROUND
A number of studies have assessed the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in oral squamous cell carcinoma (OSCC), but their results regarding the predictive value of NLR in OSCC are inconsistent. We therefore performed a meta-analysis to clarify the association between NLR and clinical outcome in OSCC.
METHODS
We searched the MEDLINE and Web of Science to identify potential studies investigating the association between NLR and survival in OSCC.
RESULTS
A total of 10 studies, enrolling 2135 patients with OSCC, were included. A higher NLR was a negative predictor for both disease-specific survival (hazard ratio [HR] = 1.93, 95% CI: 1.47-2.54) and overall survival (HR = 1.56, 95% CI: 1.28-1.90).
CONCLUSION
This suggests a higher NLR is predictive of a poorer prognosis in OSCC. Because determination of NLR is non-invasive and cost-effective, it could be widely used for predicting prognosis in OSCC.
背景
多项研究评估了中性粒细胞与淋巴细胞比值（NLR）在口腔鳞状细胞癌（OSCC）中的预后价值，但关于 NLR 在 OSCC 中的预测价值的结果并不一致。因此，我们进行了荟萃分析以阐明 NLR 与 OSCC 临床结局之间的关系。
方法
我们检索了 MEDLINE 和 Web of Science，以确定评估 NLR 与 OSCC 生存之间关联的潜在研究。
结果
共纳入了 10 项研究，纳入了 2135 例 OSCC 患者。较高的 NLR 是疾病特异性生存（风险比 [HR] = 1.93，95%CI：1.47-2.54）和总生存（HR = 1.56，95%CI：1.28-1.90）的负面预测因子。
结论
这表明较高的 NLR 预示着 OSCC 预后较差。由于 NLR 的测定是非侵入性且具有成本效益的，因此它可以广泛用于预测 OSCC 的预后。
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