TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Molecules. 2019 Apr 28;24(9):1664. doi: 10.3390/molecules24091664.
As part of our continual efforts to exploit 'Tujia Ethnomedicine' for their pharmacophoric functionalities, we herein investigated collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,15-trihydroxycadinan-4-en-3-one (), (+)-3,11,12-trihydroxycalamenene (), (-)-3,10,11,12-tetrahydroxy-calamenene (), along with four known sesquiterpenes (-), and a cytochalasin H (). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound exhibited a strong antioxidant effect with an IC value of 3.67 µM on isolated human polymorphonuclear cells or neutrophils.
作为我们不断努力挖掘土家族民族医学的药效功能的一部分，我们从湖南省北部武陵山区采集并分离出三种新的倍半萜：6α,9α,15-三羟基卡丹宁-4-烯-3-酮（）、（+）-3,11,12-三羟基菖蒲烯（）、（-）-3,10,11,12-四羟基菖蒲烯（），以及四种已知的倍半萜：和细胞松弛素 H（）。通过 1D-和 2D-NMR 光谱以及 HRESI-MS、CD 光谱解析了它们的化学结构。评估了这些化合物的抗氧化和细胞毒性活性。化合物在离体人多形核细胞或中性粒细胞上的 IC 值为 3.67µM，表现出很强的抗氧化作用。
