Hsu M M, Lin B L
Ann Otol Rhinol Laryngol. 1986 May-Jun;95(3 Pt 1):298-301. doi: 10.1177/000348948609500317.
Peripheral blood T cell subsets from 99 patients with nasopharyngeal carcinoma (NPC), 38 age-matched healthy subjects, and 20 patients with head and neck cancer other than NPC were characterized by reactivity with monoclonal antibodies. Patients with NPC showed much lower values of percentage and absolute number of common T cells (OKT3+) and helper cells (OKT4+) (p less than 0.01) than the control groups. The percentage of suppressor cells (OKT8+) was found to be higher in NPC patients than in healthy persons (p less than 0.001), but the absolute number was still lower in NPC patients. A selective decrease in the ratios of OKT4+ to OKT8+ cells was found in NPC patients (p less than 0.001). The ratios were correlated inversely to the clinical stage (r = 0.294, p less than 0.01). After negative selection by complement-mediated cytolysis, the remaining cells were stimulated with phytohemagglutinin. Net counts of isotope incorporation were smaller in all T cell subsets of NPC patients (p less than 0.001). These data indicate that the depressed cell-mediated immunity in NPC patients is due to inadequate number and functions of T cell subsets and a relative increased proportion of suppressor T cells.
采用单克隆抗体反应特性对99例鼻咽癌患者、38例年龄匹配的健康受试者以及20例非鼻咽癌的头颈癌患者的外周血T细胞亚群进行了表征。鼻咽癌患者的普通T细胞（OKT3 +）和辅助性T细胞（OKT4 +）的百分比和绝对数量值比对照组低得多（p <0.01）。发现鼻咽癌患者的抑制性T细胞（OKT8 +）百分比高于健康人（p <0.001），但鼻咽癌患者的绝对数量仍然较低。在鼻咽癌患者中发现OKT4 +与OKT8 +细胞的比例选择性降低（p <0.001）。这些比例与临床分期呈负相关（r = 0.294，p <0.01）。通过补体介导的细胞溶解进行阴性选择后，用植物血凝素刺激剩余细胞。鼻咽癌患者所有T细胞亚群的同位素掺入净计数较小（p <0.001）。这些数据表明，鼻咽癌患者细胞介导的免疫功能低下是由于T细胞亚群数量和功能不足以及抑制性T细胞比例相对增加所致。
