一项病例对照研究及荟萃分析证实，葡萄糖激酶调节基因rs780094是妊娠期糖尿病的一个风险因素。

A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes mellitus.

作者信息

Jamalpour Sajad, Zain Shamsul Mohd, Mosavat Maryam, Mohamed Zahurin, Omar Siti Zawiah

机构信息

The Pharmacogenomics Laboratory, University of Malaya, Kuala Lumpur, Malaysia; Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

Gene. 2018 Apr 15;650:34-40. doi: 10.1016/j.gene.2018.01.091. Epub 2018 Jan 31.

DOI:10.1016/j.gene.2018.01.091

PMID:29410004

Abstract

BACKGROUND

Although the influence of a common variant in the glucokinase regulatory gene (GCKR rs780094) in type 2 diabetes mellitus has been well documented, less data however, is available of its role in gestational diabetes mellitus (GDM). We carried out a case control study to assess the association between GCKR rs780094 and GDM in the Asian, and also a meta-analysis to further assess the strength of the association.

METHODS

Demographic, clinical and genotype data were determined for 1122 women (267 cases and 855 controls) recruited from the University of Malaya Medical Centre in the Klang Valley, Kuala Lumpur. Relevant articles were identified from Pubmed, Embase, MEDLINE, and Web of Science. Extraction of data was carried out and summary estimates of the association between rs780094 and GDM were examined.

RESULTS

The frequency of risk allele C was significantly higher in the cases than controls (OR 1.34, 95% CI 1.09-1.66, P = 0.006). The C allele was also associated with increased level of random 2-hour fasting plasma glucose and pregravid body mass index. Meta-analysis further confirmed the association of the GCKR rs780094 with GDM (OR 1.32, 95% CI 1.14-1.52, P = 0.0001).

CONCLUSION

This study strongly suggests that GCKR rs780094-C is associated with increased risk of GDM.

摘要

背景

尽管葡萄糖激酶调节基因（GCKR rs780094）中的常见变异对2型糖尿病的影响已有充分记录，但关于其在妊娠期糖尿病（GDM）中作用的数据却较少。我们进行了一项病例对照研究，以评估GCKR rs780094与亚洲人群GDM之间的关联，并进行了荟萃分析以进一步评估这种关联的强度。

方法

确定了从吉隆坡巴生谷马来亚大学医学中心招募的1122名女性（267例病例和855名对照）的人口统计学、临床和基因型数据。从PubMed、Embase、MEDLINE和科学网中检索相关文章。进行数据提取，并检查rs780094与GDM之间关联的汇总估计值。

结果

病例组中风险等位基因C的频率显著高于对照组（比值比1.34，95%置信区间1.09 - 1.66，P = 0.006）。C等位基因还与随机2小时空腹血糖水平升高和孕前体重指数增加有关。荟萃分析进一步证实了GCKR rs780094与GDM之间的关联（比值比1.32，95%置信区间1.14 - 1.52，P = 0.0001）。