Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.
J Control Release. 2018 Mar 28;274:35-55. doi: 10.1016/j.jconrel.2018.01.032. Epub 2018 Feb 1.
Treatment of critical-size bone defects is a major medical challenge since neither the bone tissue can regenerate nor current regenerative approaches are effective. Emerging progresses in the field of nanotechnology have resulted in the development of new materials, scaffolds and drug delivery strategies to improve or restore the damaged tissues. The current article reviews promising nanomaterials and emerging micro/nano fabrication techniques for targeted delivery of biomolecules for bone tissue regeneration. In addition, recent advances in fabrication of bone graft substitutes with similar properties to normal tissue along with a brief summary of current commercialized bone grafts have been discussed.
治疗临界尺寸骨缺损是一个重大的医学挑战，因为骨组织既不能再生，当前的再生方法也没有效果。纳米技术领域的新兴进展导致了新材料、支架和药物输送策略的发展，以改善或恢复受损组织。本文综述了有前途的纳米材料和新兴的微/纳米制造技术，用于生物分子的靶向输送，以促进骨组织再生。此外，还讨论了具有类似正常组织性能的骨移植物替代品的制造的最新进展，以及对当前商业化骨移植物的简要总结。
