Salus Research, Fort Wayne, Indiana 46825.
GSK Consumer Healthcare, Weybridge, Surrey, KT13 ODE, United Kingdom.
J Esthet Restor Dent. 2018 Mar;30(2):E45-E51. doi: 10.1111/jerd.12355. Epub 2018 Feb 7.
Phytate is an organic, cyclic polyphosphate analogous to linear condensed polyphosphates used as stain removal agents. This study investigated stain removal efficacy of an experimental sodium phytate-containing dentifrice compared to a reference dentifrice.
An experimental, moderate abrasivity (relative dentine abrasivity [RDA] ∼130) antisensitivity fluoride dentifrice containing sodium phytate (0.85% w/w as the hexasodium salt) (n = 111) was compared to a reference, marketed, low-abrasivity (RDA ∼ 43), anti-sensitivity fluoride dentifrice (n = 113), both containing 1150 ppm fluoride as sodium fluoride. Primary efficacy variables were between-treatment differences in extrinsic dental stain of anterior teeth after 6 and 12 weeks' twice-daily use, using Lobene stain index (MacPherson modification, MLSI) mean area (A) and intensity (I) scores. Comparisons included whole-tooth and hard-to-reach areas (gingival, interproximal, body of lingual).
At both 6- and 12-week timepoints, MLSI (A × I) scores for total area and hard-to-reach areas for the experimental dentifrice were statistically significantly lower than baseline (P < .0001 for all). This was demonstrated for the reference dentifrice at 6 weeks only, for total, interproximal (P < .0001 for both), and body of lingual (P = .0395) scores. Compared with the reference, the experimental dentifrice had statistically significantly lower MLSI scores at both 6 and 12 weeks for all outcome variables including both total MLSI (A × I) and hard-to reach areas (P < .0001 in all cases). Products were generally well-tolerated.
Differences between treatments were considered clinically differentiable. Sodium phytate may therefore be a suitable additive ingredient to improve tooth stain control performance within an otherwise conventional dentifrice formulation.
Following 6 and 12 weeks brushing, clinically differentiable differences were shown in stain index scores with an experimental dentifrice containing sodium phytate compared to a reference dentifrice without sodium phytate. Sodium phytate may therefore be a suitable additive ingredient to improve tooth stain control performance within an otherwise conventional dentifrice formulation.
植酸是一种有机环状多磷酸盐，类似于用作去污剂的线性缩合多磷酸盐。本研究比较了一种含植酸钠的实验性牙膏的去污效果，这种牙膏具有中等磨蚀性（相对牙本质磨蚀率 [RDA] 约为 130），并具有抗敏感作用，同时还含有氟化物。
一种实验性、中度磨蚀性（相对牙本质磨蚀率 [RDA] 约 130）、抗敏感含氟牙膏，含有植酸钠（0.85%w/w 为六钠盐）（n=111），与一种参考的市售、低磨蚀性（RDA 约为 43）、抗敏感含氟牙膏（n=113）进行比较，后者均含有 1150ppm 氟化物作为氟化钠。主要疗效变量是在使用 6 和 12 周后，使用 Lobene 染色指数（MacPherson 改良法，MLSI）的均值面积（A）和强度（I）评分，比较前门牙的外源性牙齿染色差异。比较包括整个牙齿和难以触及的区域（牙龈、邻间、舌体）。
在 6 周和 12 周的时间点，实验牙膏的 MLSI（A×I）总区域和难以触及区域的评分均低于基线（所有 P<.0001）。参考牙膏仅在 6 周时显示出这一点，总评分、邻间（均 P<.0001）和舌体（P=0.0395）评分。与参考牙膏相比，在所有结局变量中，包括总 MLSI（A×I）和难以触及区域，实验牙膏在 6 周和 12 周的 MLSI 评分均具有统计学意义的显著降低（所有情况下 P<.0001）。产品普遍耐受性良好。
处理之间的差异被认为具有临床可区分性。因此，植酸钠可能是一种合适的添加剂成分，可改善常规牙膏配方中牙齿染色控制性能。
在使用含植酸钠的实验牙膏和不含植酸钠的参考牙膏刷牙 6 周和 12 周后，在染色指数评分上显示出具有临床可区分性的差异。因此，植酸钠可能是一种合适的添加剂成分，可改善常规牙膏配方中牙齿染色控制性能。
