Mason Stephen, Hughes Nathan, Layer Teresa
GlaxoSmithKline Consumer Healthcare, Weybridge, UK.
J Clin Dent. 2009;20(5):167-73.
There have been many recent articles and reviews covering the effectiveness of dentifrices for the treatment and relief of dentin sensitivity. To date, there are no articles which fully examine all the compromises that a dentifrice formulator and manufacturer have to make when developing an effective dentifrice technology in the context of theoretical approaches and proposed modes of action. This article provides a first review and discussion of the currently available technologies, nerve depolarization and occluding agents. The generalized formulation strategies and approaches of dentifrices containing these agents are discussed, demonstrating that simplified conclusions with regard to efficacy should be drawn with caution.
最近有许多文章和综述涉及牙膏治疗和缓解牙本质敏感的有效性。迄今为止，尚无文章全面探讨牙膏配方师和制造商在理论方法和拟议的作用模式背景下开发有效牙膏技术时必须做出的所有权衡。本文首次对目前可用的技术、神经去极化剂和封闭剂进行综述和讨论。讨论了含有这些成分的牙膏的一般配方策略和方法，表明应谨慎得出关于功效的简化结论。
