Mathias C G, Andersen K E, Hamann K
Contact Dermatitis. 1983 Nov;9(6):507-9. doi: 10.1111/j.1600-0536.1983.tb04473.x.
Severe allergic contact dermatitis from a paint mildewcide, 2-n-octyl-4-isothiazolin-3-one, developed in a worker formulating latex paints within a paint manufacturing company, Guinea pig maximization testing demonstrated this to be a moderate sensitizer. Further cases of allergic contact dermatitis may be encountered as the use of this biocide increases in the market place.
一名在涂料制造公司调配乳胶漆的工人，因接触一种涂料防霉剂2-正辛基-4-异噻唑啉-3-酮，患上了严重的过敏性接触性皮炎。豚鼠最大化试验表明该物质为中度致敏剂。随着这种杀菌剂在市场上的使用增加，可能会出现更多过敏性接触性皮炎病例。
