Jiangsu University, Zhenjiang, People's Republic of China.
Jiangsu University, Zhenjiang, People's Republic of China.
Prog Mol Biol Transl Sci. 2018;154:147-168. doi: 10.1016/bs.pmbts.2017.11.001. Epub 2018 Jan 19.
Sirtuins are a family of intracellular enzymes whose enzymatic activities include catalyzing the β-nicotinamide adenine dinucleotide (β-NAD)-dependent N-acyl-lysine deacylation and the β-NAD-dependent mono-ADP-ribosylation. Among the seven sirtuin family members (i.e., SIRT1-7) thus far identified in mammals including humans, we know SIRT1/2/3/5/6 better than SIRT4/7 as for their enzymatic activities and the cellular roles of the reactions they catalyze. This chapter will provide an updated account on the enzymology and biology of SIRT4 and SIRT7, the two less well-understood mammalian sirtuins. It is hoped that this article will also be able to set a stage for the medicinal chemistry work on SIRT4 and SIRT7, potentially developing novel therapeutic agents for human diseases.
Sirtuins 是一类细胞内酶，其酶活性包括催化 β-烟酰胺腺嘌呤二核苷酸 (β-NAD) 依赖性 N-酰基赖氨酸脱酰基和 β-NAD 依赖性单 ADP-核糖基化。在哺乳动物（包括人类）中已鉴定出的 7 种 Sirtuin 家族成员中，我们对 SIRT1/2/3/5/6 的了解比对 SIRT4/7 更多，因为它们的酶活性和它们催化的反应的细胞作用。本章将提供关于 SIRT4 和 SIRT7 的酶学和生物学的最新描述，这两种哺乳动物 Sirtuin 了解得较少。希望本文也能为 SIRT4 和 SIRT7 的药物化学研究奠定基础，从而为人类疾病开发新型治疗药物。
