基于环肽的 Sirtuin 底物。
Cyclic Peptide-Based Sirtuin Substrates.
机构信息
School of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.
出版信息
Molecules. 2019 Jan 24;24(3):424. doi: 10.3390/molecules24030424.
Abstract
In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring N-acetyl-lysine or N-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the / ratios.
摘要
在当前研究中，发现四个侧链到侧链环肽（三个 5 肽和一个 4 肽）含有 N-乙酰-赖氨酸或 N-豆蔻酰-赖氨酸，作为体外人类 SIRT1/2/3 催化脱酰基的底物具有良好的底物活性，这可以通过 / 比值来判断。
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