Grupo de Química de Materiais Híbridos e Inorgânicos, Prédio de Química Ambiental, Instituto de Química de São Carlos, Universidade de São Paulo, 13563-120, São Carlos, SP, Brazil.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, UNLP - CONICET, CC 16 Suc 4(1900) La Plata, Argentina.
Colloids Surf B Biointerfaces. 2018 Apr 1;164:144-154. doi: 10.1016/j.colsurfb.2017.12.016. Epub 2017 Dec 26.
Medical device-related infections represent a major healthcare complication, resulting in potential risks for the patient. Antimicrobial materials comprise an attractive strategy against bacterial colonization and biofilm proliferation. However, in most cases these materials are only bacteriostatic or bactericidal, and consequently they must be used in combination with other antimicrobials in order to reach the eradication condition (no viable microorganisms). In this study, a straightforward and robust antibacterial coating based on Phosphotungstate Ormosil doped with core-shell (SiO@TiO) was developed using sol-gel process, chemical tempering, and Ag nanoparticle photoassisted synthesis (POrs-CS-Ag). The coating was characterized by X-ray Fluorescence Spectroscopy (XRF), Field Emission Scanning Electron Microscopy (FE-SEM), Atomic Force Microscopy (AFM) and X-ray Photoelectron Microscopy (XPS). The silver free coating displays low antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, in opposition to the silver loaded ones, which are able to completely eradicate these strains. Moreover, the antimicrobial activity of these substrates remains high until three reutilization cycles, which make them a promising strategy to develop self-sterilizing materials, such as POrs-CS-Ag-impregnated fabric, POrs-CS-Ag coated indwelling metals and polymers, among other materials.
医疗器械相关感染是一种主要的医疗保健并发症，会给患者带来潜在风险。抗菌材料是对抗细菌定植和生物膜增殖的一种有吸引力的策略。然而，在大多数情况下，这些材料只是抑菌或杀菌的，因此它们必须与其他抗菌药物联合使用，以达到消除条件（无存活微生物）。在这项研究中，使用溶胶-凝胶工艺、化学回火和 Ag 纳米颗粒光辅助合成（POrs-CS-Ag），开发了一种基于掺杂核壳（SiO@TiO）的膦钨酸盐 Ormosil 的简单而强大的抗菌涂层。该涂层通过 X 射线荧光光谱（XRF）、场发射扫描电子显微镜（FE-SEM）、原子力显微镜（AFM）和 X 射线光电子能谱（XPS）进行了表征。不含银的涂层对金黄色葡萄球菌和铜绿假单胞菌的抗菌活性较低，而负载银的涂层则能够完全消除这些菌株。此外，这些基底的抗菌活性在三个再利用周期内仍然很高，这使它们成为开发自消毒材料的有前途的策略，如 POrs-CS-Ag 浸渍织物、POrs-CS-Ag 涂层留置金属和聚合物等材料。
