Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, United States.
Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, United States.
Curr Opin Cell Biol. 2018 Jun;52:43-50. doi: 10.1016/j.ceb.2018.01.004. Epub 2018 Feb 4.
DNA replication proceeds along spatially and temporally coordinated patterns within the nucleus, thus protecting the genome during the synthesis of new genetic material. While we have been able to visualize replication patterns on DNA fibers for 50 years, recent developments and discoveries have provided a greater insight into how DNA replication is controlled. In this review, we highlight many of these discoveries. Of great interest are the physiological role of the replication timing program, cis and trans-acting factors that modulate replication timing and the effects of chromatin structure on the replication timing program. We also discuss future directions in the study of replication timing.
DNA 复制沿着细胞核内的时空协调模式进行，从而在合成新遗传物质的过程中保护基因组。虽然我们已经能够在 DNA 纤维上观察复制模式长达 50 年，但最近的发展和发现为我们提供了更多关于 DNA 复制如何受到控制的深入了解。在这篇综述中，我们强调了其中的许多发现。特别引人关注的是复制时间程序的生理作用、调节复制时间的顺式和反式作用因子，以及染色质结构对复制时间程序的影响。我们还讨论了复制时间研究的未来方向。
