From the Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110.
From the Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110
J Biol Chem. 2018 Feb 2;293(5):1515-1516. doi: 10.1074/jbc.H118.001463.
The type VI secretion system (T6SS) delivers toxic effectors between Gram-negative bacteria. Most antibacterial T6SS effectors are peptidoglycanases, nucleases, or lipases. In the current work, Tang structurally and functionally characterize a novel family of NAD(P)-hydrolyzing effectors (NADases), thus expanding the documented types of T6SS substrates. Bioinformatic identification of NADase family members putatively secreted by the bacteriolytic type VII secretion system (T7SS) of Gram-positive bacteria further points to NADases as a diverse and important class of effectors.
VI 型分泌系统（T6SS）在革兰氏阴性菌之间传递毒性效应器。大多数抗菌 T6SS 效应器是肽聚糖酶、核酸酶或脂肪酶。在本工作中，Tang 对一类新型 NAD(P)水解效应器（NADase）进行了结构和功能表征，从而扩展了 T6SS 底物的已有类型。通过生物信息学鉴定，推测革兰氏阳性菌的裂解性 VII 型分泌系统（T7SS）分泌的 NADase 家族成员，进一步表明 NADase 是一类多样且重要的效应器。
