Jarero-Basulto José J, Gasca-Martínez Yadira, Rivera-Cervantes Martha C, Ureña-Guerrero Mónica E, Feria-Velasco Alfredo I, Beas-Zarate Carlos
Cellular Neurobiology Laboratory, Cell and Molecular Biology Department, CUCBA, University of Guadalajara, 45220 Zapopan, Jalisco, Mexico.
Neurotransmission Biology Laboratory, Cell and Molecular Biology Department, CUCBA, University of Guadalajara, 45220 Zapopan, Jalisco, Mexico.
Pharmaceuticals (Basel). 2018 Feb 7;11(1):17. doi: 10.3390/ph11010017.
Undoubtedly, one of the most interesting topics in the field of neuroscience is the ability of the central nervous system to respond to different stimuli (normal or pathological) by modifying its structure and function, either transiently or permanently, by generating neural cells and new connections in a process known as neuroplasticity. According to the large amount of evidence reported in the literature, many stimuli, such as environmental pressures, changes in the internal dynamic steady state of the organism and even injuries or illnesses (e.g., epilepsy) may induce neuroplasticity. Epilepsy and neuroplasticity seem to be closely related, as the two processes could positively affect one another. Thus, in this review, we analysed some neuroplastic changes triggered in the hippocampus in response to seizure-induced neuronal damage and how these changes could lead to the establishment of temporal lobe epilepsy, the most common type of focal human epilepsy.
毫无疑问，神经科学领域最有趣的话题之一是中枢神经系统通过神经可塑性过程生成神经细胞和新连接，从而暂时或永久地改变其结构和功能，以响应不同刺激（正常或病理刺激）的能力。根据文献报道的大量证据，许多刺激，如环境压力、机体内部动态稳态的变化，甚至损伤或疾病（如癫痫）都可能诱发神经可塑性。癫痫和神经可塑性似乎密切相关，因为这两个过程可能会相互产生积极影响。因此，在本综述中，我们分析了海马体中因癫痫发作引起的神经元损伤而触发的一些神经可塑性变化，以及这些变化如何导致颞叶癫痫的发生，颞叶癫痫是人类最常见的局灶性癫痫类型。
