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南海鳍藻中的新 norisoprenoids。

Norisoprenoids from the Brown Alga Sargassum naozhouense Tseng et Lu.

机构信息

Life Science and Technology School, Lingnan Normal University, Cunjin Road 29, Zhanjiang 524048, China.

Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Xinggang West Road 164, Guangzhou 510301, China.

出版信息

Molecules. 2018 Feb 7;23(2):348. doi: 10.3390/molecules23020348.

DOI:10.3390/molecules23020348
PMID:29414891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6017521/
Abstract

A new C-norisoprenoid derivative, sargassumone (), has been isolated from together with six known norisoprenoids and a highly oxygenated cyclopentene: (2,6,8,9)-hexahydro-2,9-dihydroxy-4,4,8-trimethyl-6-acetyloxy-3(2)-benzofuranone (), (6,8,9)-hexahydro-6,9-dihydroxy-4,4,8-trimethyl-2(2)-benzofuranone (), (6,8,9)-hexahydro-6,9-dihydroxy-4,4,8-trimethyl-2(2)-benzofuranone (), loliolide (), (+)-epiloliolide (), spheciospongones A (), and (+)-kjellmanianone (). Compound was identified on the basis of nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis, and the absolute stereochemistry was defined by NOESY spectroscopy, minimizing energy calculation, and circular dichroism (CD) spectra. The known compounds -, isolated from for the first time, were identified by comparison of their physical and spectroscopic data with those reported in the literature. Compound was tested for its inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), antioxidant activity with 1,1-diphyl-2-picrylhydrazyl (DPPH) free radicals, and antimicrobial activity against resistant clinical isolates of , methicillin-resistant , and .

摘要

从 中分离得到一种新的 C-降二萜衍生物，马尾藻酮（），此外还分离得到 6 种已知的降二萜和一种高度氧化的环戊烯：(2,6,8,9)-六氢-2,9-二羟基-4,4,8-三甲基-6-乙酰氧基-3(2)-苯并呋喃酮（）、(6,8,9)-六氢-6,9-二羟基-4,4,8-三甲基-2(2)-苯并呋喃酮（）、(6,8,9)-六氢-6,9-二羟基-4,4,8-三甲基-2(2)-苯并呋喃酮（）、洛内酯（）、(+)-表洛内酯（）、spheciospongones A（）和(+)-kjellmanianone（）。根据核磁共振（NMR）和质谱（MS）分析鉴定化合物，通过 NOESY 光谱、最小化能量计算和圆二色（CD）光谱确定其绝对立体化学。首次从 中分离得到的已知化合物-，通过与文献报道的物理和光谱数据进行比较来鉴定。对化合物 进行了蛋白酪氨酸磷酸酶 1B（PTP1B）抑制活性、1,1-二苯基-2-苦基肼基（DPPH）自由基抗氧化活性和对耐甲氧西林的金黄色葡萄球菌、耐甲氧西林的表皮葡萄球菌和耐万古霉素肠球菌的抗菌活性测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/20eb1167813d/molecules-23-00348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/2bbaf5470416/molecules-23-00348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/f7e95db915fe/molecules-23-00348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/5e9977254f12/molecules-23-00348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/4441775301b9/molecules-23-00348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/20eb1167813d/molecules-23-00348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/2bbaf5470416/molecules-23-00348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/f7e95db915fe/molecules-23-00348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/5e9977254f12/molecules-23-00348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/4441775301b9/molecules-23-00348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/6017521/20eb1167813d/molecules-23-00348-g005.jpg

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