Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Int J Mol Sci. 2018 Feb 7;19(2):503. doi: 10.3390/ijms19020503.
The increasing technological applications of palladium nanoparticles (Pd-NPs) and their consequent enhancing release into the community and occupational environments, have raised public health concerns regarding possible adverse effects for exposed subjects, and particularly for workers chronically and highly exposed to these materials, whose toxico-kinetic and dynamic behavior remains to be fully understood. Therefore, this review aimed to critically analyze literature data to achieve a more comprehensive knowledge on the toxicological profile of Pd-NPs. Results from available studies demonstrated the potential for these chemicals to affect the ecosystem function, to exert cytotoxic and pro-inflammatory effects in vitro as well as to induce early alterations in different target organs in in vivo models. However, our revision pointed out the need for future studies aimed to clarify the role of the NP physico-chemical properties in determining their toxicological behavior, as well as the importance to carry out investigations focused on environmental and biological monitoring to verify and validate experimental biomarkers of exposure and early effect in real exposure contexts. Overall, this may be helpful to support the definition of suitable strategies for the assessment, communication and management of Pd-NP occupational risks to protect the health and safety of workers.
钯纳米粒子（Pd-NPs）的应用日益增多，并且随之越来越多地释放到社区和职业环境中，这引起了公众对可能对暴露人群产生不利影响的关注，特别是对长期和高度接触这些材料的工人，他们的毒代动力学和动态行为仍有待充分了解。因此，本综述旨在批判性地分析文献数据，以更全面地了解 Pd-NPs 的毒理学特征。现有研究结果表明，这些化学物质有可能影响生态系统功能，在体外产生细胞毒性和促炎作用，并在体内模型中诱导不同靶器官的早期改变。然而，我们的综述指出，需要进行未来的研究，以阐明 NP 的物理化学性质在确定其毒理学行为中的作用，以及开展环境和生物监测研究的重要性，以验证和验证实际暴露环境中暴露和早期效应的实验生物标志物。总的来说，这有助于支持制定适当的策略，以评估、沟通和管理 Pd-NP 职业风险，保护工人的健康和安全。
