Department of Medical Oncology, Jinling Hospital, Nanjing Clinical School of Southern Medical University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, China.
Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu, 210002, China.
Mol Cancer. 2018 Feb 7;17(1):22. doi: 10.1186/s12943-018-0766-4.
Angiogenesis is essential for tumor growth and metastasis. Understanding the regulation of tumor angiogenesis has become increasingly important. MicroRNAs (miRNAs) are small noncoding RNAs that function in diverse biological processes via post-transcriptional regulation. Extensive studies have revealed two important regulatory roles of miRNAs in tumor angiogenesis: miRNAs in tumor cells affect the activity of endothelial cells via non-cell-autonomous mechanisms, and miRNAs in endothelial cells regulate the cell-autonomous behavior. Recent advances have further highlighted the role of tumor-derived extracellular vesicles in the regulation of tumor angiogenesis via transferring miRNAs to endothelial cells. In this review, we summarize the regulatory role of miRNA in tumor angiogenesis, with a highlight on clinical implications of miRNAs as biomarkers for anti-angiogenic therapy response, and as therapeutic interventions against tumor angiogenesis in vivo.
血管生成对于肿瘤的生长和转移至关重要。了解肿瘤血管生成的调控机制变得越来越重要。微小 RNA（miRNA）是一类通过转录后调控在多种生物学过程中发挥作用的小非编码 RNA。大量研究揭示了 miRNA 在肿瘤血管生成中的两个重要调控作用：肿瘤细胞中的 miRNA 通过非细胞自主机制影响内皮细胞的活性，而内皮细胞中的 miRNA 则调节细胞自主行为。最近的研究进展进一步强调了肿瘤来源的细胞外囊泡通过将 miRNA 转移到内皮细胞中在调节肿瘤血管生成中的作用。在这篇综述中，我们总结了 miRNA 在肿瘤血管生成中的调控作用，重点介绍了 miRNA 作为抗血管生成治疗反应的生物标志物的临床意义，以及作为体内抗肿瘤血管生成的治疗干预手段。
