Qi Cuiping, Jin Xiuping, Wang Hui, Xu Dan
Department of Obstetrics, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Department of Pharmacology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.
Biomolecules. 2025 Jul 28;15(8):1092. doi: 10.3390/biom15081092.
A variety of epigenetic mechanisms-such as DNA methylation, histone alterations, RNA chemical modifications, and regulatory non-coding RNAs-collectively influence gene regulation and cellular processes. Among these, N6-methyladenosine (mA) represents the most widespread internal modification in eukaryotic mRNA, exerting significant influence on RNA metabolic pathways and modulating mRNA function at multiple levels. Studies have shown that mA modification is highly enriched in the brain and regulates central nervous system development and various physiological functions. Recent studies have demonstrated that mA interacts with other epigenetic regulators and triggers epigenetic remodeling, which further affects the development and occurrence of central nervous system diseases. In this review, we provide an up-to-date overview of this emerging research hotspot in biology, with a focus on the interplay between mA and other epigenetic regulators. We highlight their potential roles and regulatory mechanisms in epigenetic reprogramming during central nervous system development and disease, offering insights into potential novel targets and therapeutic strategies for CNS disorders.
多种表观遗传机制，如DNA甲基化、组蛋白改变、RNA化学修饰和调控性非编码RNA，共同影响基因调控和细胞过程。其中，N6-甲基腺苷（m⁶A）是真核生物mRNA中最普遍的内部修饰，对RNA代谢途径有重大影响，并在多个层面调节mRNA功能。研究表明，m⁶A修饰在大脑中高度富集，调节中枢神经系统发育和各种生理功能。最近的研究表明，m⁶A与其他表观遗传调节因子相互作用并触发表观遗传重塑，进而影响中枢神经系统疾病的发生和发展。在本综述中，我们提供了这一生物学新兴研究热点的最新概述，重点关注m⁶A与其他表观遗传调节因子之间的相互作用。我们强调了它们在中枢神经系统发育和疾病过程中表观遗传重编程中的潜在作用和调控机制，为中枢神经系统疾病的潜在新靶点和治疗策略提供了见解。
