Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Cell Mol Med. 2021 Mar;25(6):2776-2785. doi: 10.1111/jcmm.16359. Epub 2021 Feb 14.
Angiogenesis plays an important role in tumour progression. However, anti-angiogenesis therapy of inhibiting pro-angiogenic factors failed to meet expectations in certain types of tumour in clinical trials. Recent studies reveal that tumour-derived extracellular vesicles (EVs) are essential in tumour angiogenesis and anti-angiogenesis drug resistance. This function has most commonly been attributed to EV contents including proteins and non-coding RNAs. Here, we summarize the recent findings of tumour-derived EV contents associated with regulating angiogenesis and illustrate the underlying mechanisms. In addition, the roles of EVs in tumour microenvironmental cells are also illustrated with a focus on how EVs participate in cell-cell communication, contributing to tumour-mediated angiogenesis. It will help offer new perspectives on developing targets of anti-angiogenesis drugs and improve the efficacy of anti-angiogenesis therapies based on tumour-derived EVs.
血管生成在肿瘤进展中起着重要作用。然而，在临床试验中，抑制促血管生成因子的抗血管生成疗法并未达到某些类型肿瘤的预期效果。最近的研究表明，肿瘤来源的细胞外囊泡（EVs）在肿瘤血管生成和抗血管生成药物耐药性中是必不可少的。这种功能通常归因于 EV 包含的内容物，包括蛋白质和非编码 RNA。在这里，我们总结了与调节血管生成相关的肿瘤来源 EV 内容物的最新发现，并阐述了其潜在机制。此外，还阐述了 EV 在肿瘤微环境细胞中的作用，重点介绍了 EV 如何参与细胞间通讯，从而促进肿瘤介导的血管生成。这将有助于为抗血管生成药物的靶点开发提供新的视角，并提高基于肿瘤来源 EV 的抗血管生成治疗的疗效。
