Marsden J R
J R Soc Med. 1985;78 Suppl 10(Suppl 10):25-8.
Treatment of acne prior to referral was recorded retrospectively in 72 patients alleged to have responded inadequately; 60% had used benzoyl peroxide (BP) but most applied it to lesions only. Although 86% had used tetracycline, most did not take it correctly for maximum absorption and took less than 1 g/day. Most patients used both drugs for less than three months. Eight-two patients referred because of inadequate response were treated with: (I) 5% benzoyl peroxide (BP) (23 patients); (II) 5% BP and 0.5 g/day oxytetracycline (OTC) (24 patients); (III) 5% BP and 1 g/day OTC (18 patients); (IV) 5% BP and 1.5 g/day OTC (17 patients). BP was applied incrementally from 30 min up to 8-10 hours daily to the entire area affected and OTC taken as a single morning dose. Median grade of severity (0-10 analogue scale) fell by 2 in Groups I and II (P less than 0.05), by 2.5 in Group III (P less than 0.05) and by 3 in Group IV (P less than 0.05); number of lesions fell by 56% +/- 7% (s.e.), (P less than 0.001) 70% +/- less than 10% (P less than 0.001), 75% +/- 8% (P less than 0.001) and 78% +/- 10% (P less than 0.001) respectively and treatment was well tolerated. Thus, although effective drugs are frequently prescribed in acne, method of use, dose and duration are likely to determine response.
在72名据称治疗效果不佳的患者中，回顾性记录了转诊前的痤疮治疗情况；60%的患者使用过过氧化苯甲酰（BP），但大多数仅将其用于皮损处。虽然86%的患者使用过四环素，但大多数未正确服用以达到最大吸收量，且每日服用量不足1克。大多数患者使用这两种药物的时间均不足三个月。因治疗效果不佳而转诊的82名患者接受了以下治疗：（I）5%过氧化苯甲酰（BP）（23例患者）；（II）5% BP和每日0.5克土霉素（OTC）（24例患者）；（III）5% BP和每日1克OTC（18例患者）；（IV）5% BP和每日1.5克OTC（17例患者）。BP每天从30分钟开始逐渐增加涂抹时间，直至每日涂抹8 - 10小时于整个受累区域，OTC则作为单次晨起剂量服用。严重程度中位数（0 - 10类比量表）在第一组和第二组下降了2（P < 0.05），在第三组下降了2.5（P < 0.05），在第四组下降了3（P < 0.05）；皮损数量分别下降了56% ± 7%（标准误）（P < 0.001）、70% ± 小于10%（P < 0.001）、75% ± 8%（P < 0.001）和78% ± 10%（P < 0.001），且治疗耐受性良好。因此，虽然痤疮治疗中经常开具有效药物，但使用方法、剂量和疗程可能决定治疗效果。
