Xu Zhijie, Yan Yuanliang, Zeng Shuangshuang, Dai Shuang, Chen Xi, Wei Jie, Gong Zhicheng
Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Pathology, School of Basic Medicine, Central South University, Changsha 410008, China.
Oncotarget. 2017 Dec 1;9(1):1444-1460. doi: 10.18632/oncotarget.22846. eCollection 2018 Jan 2.
Circular RNAs, as recently discovered new endogenous non-coding RNAs, are important gene modulators with critical roles in tumor initiation and malignant progression. With the development of RNA sequencing and microarray technologies, numerous of functional circRNAs have been identified in cancerous tissues and cell lines. Mechanistically, circRNAs function as miRNA sponges, miRNA reservoirs or parental gene expression regulators. In this review, we discuss the properties and functions of circRNAs and their clinical implication as promising biomarkers for cancer research. Moreover, some emerging fields, such as exosome-loaded and immune response-associated circRNAs, are also discussed, suggesting novel insights into the carcinogenesis and therapy associated with these molecules.
环状RNA作为最近发现的新型内源性非编码RNA，是重要的基因调节因子，在肿瘤发生和恶性进展中起关键作用。随着RNA测序和微阵列技术的发展，在癌组织和细胞系中已鉴定出许多功能性环状RNA。从机制上讲，环状RNA可作为微小RNA（miRNA）海绵、miRNA储存库或亲本基因表达调节剂。在本综述中，我们讨论了环状RNA的特性和功能及其作为癌症研究中有前景的生物标志物的临床意义。此外，还讨论了一些新兴领域，如外泌体携带的环状RNA和免疫反应相关的环状RNA，为这些分子相关的致癌作用和治疗提供了新的见解。
