Variants in the APOB gene was associated with Ischemic Stroke susceptibility in Chinese Han male population.

BACKGROUND

Stroke is an extremely complicated disease caused by multiple factors. Epidemiological studies have shown that genetic factors contribute to the pathogenesis of stroke. There is still little research on the effect of gene on stroke in Chinese Han population. The purpose of our research was to explore the effect of gene polymorphism on the genetic susceptibility to Ischemic Stroke in Chinese Han male population.

MATERIALS AND METHODS

7 polymorphisms in gene were selected and genotyped using Sequenom MassARRAY in 325 ischemic stroke male patients and 399 healthy male controls in Chinese Han population. The association between gene and genetic susceptibility to Ischemic Stroke was performed by the χ test, genetic model analysis and haplotype analysis.

RESULTS

In the allele model, rs1042034 "T" allele and rs673548 "G" allele increased the risk of the Ischemic Stroke (rs1042034: OR=1.29, 95%CI: 1.02-1.63, p=0.030; rs673548: OR=1.28, 95%CI: 1.02-1.62, p=0.034). Logistic regression analysis found that rs1042034 and rs673548 increased the risk of Ischemic Stroke in the log-additive model, the odds of having Ischemic Stroke would be 1.28-fold and 1.27-fold with the variant allele, respectively. We also found that the risk of individuals carrying the rs693 "AA-AG" genotype had Ischemic Stroke risk of 1.52-fold of carrying "GG" genotype in the dominant model. The haplotype analysis shown that "TAG" haplotype raised the risk of Ischemic Stroke (OR=1.52, 95%CI: 1.02-2.27, p=0.0042).

CONCLUSION

The polymorphisms of the gene may affect Ischemic Stroke occurrence.