Ma Liang, Wang Shaoting, Zhao Hailing, Yu Meijie, Deng Xiangling, Jiang Yongwei, Cao Yongtong, Li Ping, Niu Wenquan
Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
Beijing Key Laboratory of Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China.
Front Med (Lausanne). 2021 Apr 6;8:659188. doi: 10.3389/fmed.2021.659188. eCollection 2021.
This study aimed to investigate the susceptibility of 8 polymorphisms in and genes to diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes mellitus. This is a case-control association study, including 575 DKD cases and 653 controls. Genotypes were determined using ligase detection reaction method, and data are analyzed using STATA software. The genotype distributions of rs1042034 and rs12720838 differed significantly between the two groups ( < 0.001 and = 0.008, respectively). After adjusting for confounding factors, the mutations of rs1042034 and rs12720838 were associated with the significantly increased risk of DKD. For instance, carriers of rs1042034 T allele (CT and TT genotypes) were 1.07 times more likely to have DKD than carriers of rs1042034 CC genotype [odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.03-1.10, < 0.001]. Further, haplotype T-A-G-T in gene was overrepresented in cases (18.10%) compared with controls (12.76%) (P = 0.045), and haplotype T-A-G-T was associated with a 33% increased risk of DKD (OR = 1.33, 95% CI: 1.04, 1.70). In further haplotype-phenotype analysis, significant association was only noted for hypertension and omnibus haplotypes in gene (P = 0.001). Our findings indicate that gene is a candidate gene for DKD in Chinese patients with type 2 diabetes mellitus.
本研究旨在探讨中国2型糖尿病患者中 基因和 基因的8个多态性位点与糖尿病肾病（DKD）的易感性。这是一项病例对照关联研究，包括575例DKD患者和653例对照。采用连接酶检测反应法确定基因型，并使用STATA软件进行数据分析。两组之间rs1042034和rs12720838的基因型分布存在显著差异（分别为<0.001和 = 0.008）。在调整混杂因素后，rs1042034和rs12720838的突变与DKD风险显著增加相关。例如，rs1042034 T等位基因（CT和TT基因型）携带者患DKD的可能性是rs1042034 CC基因型携带者的1.07倍[比值比（OR）= 1.07，95%置信区间（CI）：1.03 - 1.10，<0.001]。此外， 基因中的单倍型T - A - G - T在病例组（18.10%）中的比例高于对照组（12.76%）（P = 0.045），并且单倍型T - A - G - T与DKD风险增加33%相关（OR = 1.33，95% CI：1.04，1.70）。在进一步的单倍型 - 表型分析中，仅在 基因中的高血压和综合单倍型方面发现了显著关联（P = 0.001）。我们的研究结果表明， 基因是中国2型糖尿病患者DKD的候选基因。
