小梁切除术对原发性开角型青光眼患者血清脑源性神经营养因子水平的影响
The effect of trabeculectomy on serum brain-derived neurotrophic factor levels in primary open-angle glaucoma.
作者信息
Uzel Mehmet Murat, Elgin Ufuk, Boral Barış, Çiçek Muharrem, Şen Emine, Şener Burçin, Yılmazbaş Pelin
机构信息
Afyonkarahisar State Hospital, 03030, Afyonkarahisar, Turkey.
University of Health Sciences, Ulucanlar Eye Research and Training Hospital, Ankara, Turkey.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2018 Jun;256(6):1173-1178. doi: 10.1007/s00417-018-3923-y. Epub 2018 Feb 7.
PURPOSE
We aimed to investigate the effect of trabeculectomy on serum brain-derived neurotrophic factor (BDNF) levels. Our secondary goal was to compare serum and aqueous humor (AH) BDNF levels in primary open-angle glaucoma (POAG) and control subjects.
METHODS
This prospective, cross-sectional study consists of 20 eyes of with advanced-stage POAG who had trabeculectomy and 19 eyes of age- and sex-matched control healthy subjects who had cataract surgery. Serum and AH samples were obtained preoperatively in trabeculectomy group and control subjects. Serum samples were obtained at the third postoperative month in both groups.
RESULTS
The aqueous humor and serum levels of BDNF at the surgery day were found to be strongly positive correlated (r = 0.868; p < 0.001). Serum and AH BDNF levels of POAG cases were significantly lower than control subjects at the surgery day (respectively p = 0.038, p = 0.011). In POAG cases, serum BDNF levels significantly increased at the third month after trabeculectomy while there was not a significant difference in control subjects with cataract surgery (p < 0.001; p = 0.717 respectively).
CONCLUSION
Trabeculectomy was found to have a positive effect on serum BDNF levels in POAG cases.
目的
我们旨在研究小梁切除术对血清脑源性神经营养因子（BDNF）水平的影响。我们的次要目标是比较原发性开角型青光眼（POAG）患者和对照受试者血清及房水（AH）中的BDNF水平。
方法
这项前瞻性横断面研究包括20例接受小梁切除术的晚期POAG患者的眼睛和19例年龄及性别匹配的接受白内障手术的对照健康受试者的眼睛。在小梁切除术组和对照受试者中，术前采集血清和AH样本。两组均在术后第三个月采集血清样本。
结果
手术当天房水和血清中的BDNF水平呈强正相关（r = 0.868；p < 0.001）。手术当天，POAG患者的血清和AH BDNF水平显著低于对照受试者（分别为p = 0.038，p = 0.011）。在POAG患者中，小梁切除术后第三个月血清BDNF水平显著升高，而接受白内障手术的对照受试者则无显著差异（分别为p < 0.001；p = 0.717）。
结论
发现小梁切除术对POAG患者的血清BDNF水平有积极影响。
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