Peking University Health Science Center, Beijing 100191, People's Republic of China.
Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education/Key Laboratory of Reproduction and Genetics/Basic Medicine Science, Department of Medical Genetic and Cell Biology, Ningxia Medical University, Yinchuan 750004, People's Republic of China.
Am J Hum Biol. 2018 May;30(3):e23109. doi: 10.1002/ajhb.23109. Epub 2018 Feb 8.
Digit ratio, especially the second-to-fourth digit ratio (2D:4D), is a proxy indicator for prenatal exposure and sensitivity to sexual hormones which may influence the susceptibility to certain cancers. The aim of the present study was to investigate whether there is a possible association between 2D:4D and gastric cancer (GCA) in north Chinese women.
Photographs of the left and right hands of 167 women (controls: 113; patients: 54) were collected. Left hand, right hand, and right minus left hand (Dr-l) 2D:4D were analyzed and compared.
The GCA group presented significantly lower 2D:4D than controls (left: P < .01; right: P < .05). No significant difference was observed in Dr-l between the two groups. In patients, there were no correlations between 2D:4D and age at GCA or tumor staging.
Decreased 2D:4D (especially of the left hand) may suggest a higher prenatal testosterone (lower prenatal estrogen) exposure in north Chinese women with GCA.
二至四指比（2D：4D）是产前暴露和对性激素敏感性的替代指标，可能影响某些癌症的易感性。本研究旨在探讨 2D：4D 与中国北方女性胃癌（GCA）之间是否存在关联。
收集了 167 名女性（对照组 113 名；患者组 54 名）的左手和右手照片。分析并比较了左手、右手和右手减去左手（Dr-l）的 2D：4D。
GCA 组的 2D：4D 明显低于对照组（左手：P<.01；右手：P<.05）。两组间 Dr-l 无显著差异。在患者中，2D：4D 与 GCA 发病年龄或肿瘤分期之间无相关性。
GCA 中国北方女性左手 2D：4D 降低（尤其是左手）可能提示其胎儿期睾酮（雌激素）暴露水平较低。
