Plastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Kopcinskiego 22, 90-153, Lodz, Poland.
Applied Sports, Technology, Exercise, and Medicine (A-STEM), Swansea University, Swansea, UK.
Sci Rep. 2020 Jul 9;10(1):11369. doi: 10.1038/s41598-020-68239-0.
A prenatal sex steroid environment of high prenatal testosterone and low prenatal oestrogen inhibits lung development and may predispose individuals to be vulnerable to lung disease in later life. Therefore, the aim of this report was to investigate whether there is an association between right and left 2D:4D (biomarker of prenatal sex steroids exposure) and primary lung cancer in women and men. Also, we considered the relationship between right-left 2D:4D (Δ2D:4D, a negative correlate of high prenatal testosterone and low prenatal oestrogen) and the age of lung cancer diagnosis. The study included 109 patients (61 men) with lung cancer and 197 controls (78 men). In the study we found that: (i) women with lung cancer have lower 2D:4D compared to controls (the effect was independent of smoking), (ii) among women with cancer, age at diagnosis was positively related to 2D:4D, i.e. women with masculinized 2D:4D present earlier with the cancer than women with feminized 2D:4D, (iii) among men with lung cancer, those with the most aggressive form (small-cell lung cancer) had masculinized (low) Δ2D:4D compared to those with the less aggressive form (non-small cell lung cancer). The data suggests that masculinized right 2D:4D and Δ2D:4D are associated with a predisposition to lung cancer and/or the more aggressive forms of lung cancer.
高孕期睾酮和低孕期雌激素的产前性激素环境会抑制肺发育，并可能使个体易患晚年肺部疾病。因此，本报告的目的是调查女性和男性的右左 2D:4D（产前性激素暴露的生物标志物）与原发性肺癌之间是否存在关联。此外，我们还考虑了右-左 2D:4D（Δ2D:4D，高孕期睾酮和低孕期雌激素的负相关物）与肺癌诊断年龄之间的关系。该研究包括 109 名肺癌患者（61 名男性）和 197 名对照者（78 名男性）。在研究中，我们发现：（i）与对照组相比，患有肺癌的女性的 2D:4D 较低（这种影响独立于吸烟），（ii）在患有癌症的女性中，诊断时的年龄与 2D:4D 呈正相关，即 2D:4D 男性化的女性比 2D:4D 女性化的女性更早出现癌症，（iii）在患有肺癌的男性中，具有侵袭性更强形式（小细胞肺癌）的男性的 Δ2D:4D 比具有侵袭性较弱形式（非小细胞肺癌）的男性更低（男性化）。数据表明，右 2D:4D 和 Δ2D:4D 的男性化与肺癌易感性和/或更具侵袭性的肺癌形式有关。
