Bretsztajn Laure, Gedroyc Wladyslaw
1 Radiology Department, Imperial College Healthcare NHS Trust , London , United Kingdom.
Br J Radiol. 2018 Jul;91(1087):20170481. doi: 10.1259/bjr.20170481. Epub 2018 Mar 6.
MR-guided focussed ultrasound surgery (MRgFUS) allows for precise non-invasive thermal ablation of target tissues for a wide range of clinical applications. It is an innovative and rapidly expanding technology, which has already established itself as an effective and safe incisionless alternative in the treatment of various soft tissue tumours, with many more research studies underway to extend its therapeutic envelope. The non-invasiveness of the procedure makes FUS particularly attractive in functional neurosurgery, where existing treatment options are not suitable for all patients. Several clinical trials have demonstrated the feasibility and favourable safety profile of MR-guided focused ultrasound surgery in essential tremor, Parkinson's disease and other neurological conditions. This article reviews the existing evidence base for the neurological applications of FUS and the evidence for its emerging roles in the treatment of a range of brain disorders.
磁共振引导聚焦超声手术（MRgFUS）能够对靶组织进行精确的非侵入性热消融，适用于广泛的临床应用。它是一项创新且迅速发展的技术，已成为治疗各种软组织肿瘤的一种有效且安全的无创替代方法，目前还有更多研究正在进行，以扩大其治疗范围。该手术的非侵入性使得聚焦超声在功能神经外科中特别有吸引力，因为现有的治疗选择并不适用于所有患者。多项临床试验已证明磁共振引导聚焦超声手术在特发性震颤、帕金森病和其他神经疾病中的可行性和良好的安全性。本文综述了聚焦超声在神经学应用方面的现有证据基础，以及其在一系列脑部疾病治疗中新兴作用的证据。
