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抗菌光动力疗法作为儿童乳牙牙髓病治疗的辅助手段:病例系列。

Antimicrobial Photodynamic Therapy as a Co-adjuvant in Endodontic Treatment of Deciduous Teeth: Case Series.

机构信息

Biophotonics Applied to Science Health, Nove de Julho University, São Paulo, Brazil.

出版信息

Photochem Photobiol. 2018 Jul;94(4):760-764. doi: 10.1111/php.12902. Epub 2018 Apr 30.

DOI:10.1111/php.12902
PMID:29420856
Abstract

To assure the success of endodontic treatment, the root canal must be completely decontaminated. Thus, some methods have been researched in an attempt to effectively eliminate microorganisms from the interior of the root canal system. Among them is conventional endodontic therapy in conjunction with photodynamic therapy (PDT). Five anterior deciduous teeth were treated endodontically with the conventional technique and PDT. For PDT, 0.005% methylene blue was used as a photosensitizer and a 660 nm laser. After the conventional endodontic therapy, the photosensitizer was applied inside the root canal, 3 min of pre-irradiation time, and then, the laser was applied for 40s with an energy of 4J. Afterward, the canal was irrigated with saline solution and the sealing material of the root canal was placed. The microbiological analysis of the samples was collected before and after the treatments were performed. Observing the results obtained in this case series, which showed a bacterial reduction from 37.57% to 100%, and the clear difficulty in the success of endodontic treatment of deciduous teeth, antimicrobial photodynamic therapy can be considered an alternative of easy application that does not generate microbial resistance, to act as a support in the decontamination of the root canals.

摘要

为确保牙髓治疗的成功,根管必须彻底消毒。因此,已经研究了一些方法,试图从根管系统内部有效消除微生物。其中之一是常规根管治疗联合光动力疗法(PDT)。用常规技术和 PDT 对五颗前乳牙进行根管治疗。对于 PDT,使用 0.005%亚甲蓝作为光敏剂和 660nm 激光。在常规根管治疗后,将光敏剂应用于根管内,预照射 3 分钟,然后用 4J 的能量照射激光 40 秒。然后,用生理盐水冲洗根管并放置根管密封材料。在治疗前后收集样本的微生物分析。观察该病例系列的结果,显示细菌减少了 37.57%到 100%,以及乳牙牙髓治疗成功的明显困难,抗菌光动力疗法可以被认为是一种易于应用的替代方法,不会产生微生物耐药性,作为根管消毒的支持手段。

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Lasers Med Sci. 2025 Jul 21;40(1):322. doi: 10.1007/s10103-025-04570-0.
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Photodynamic Therapy for Treatment of Disease in Children-A Review of the Literature.儿童疾病的光动力治疗——文献综述
Children (Basel). 2022 May 10;9(5):695. doi: 10.3390/children9050695.
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How can biophotonics help dentistry to avoid or minimize cross infection by SARS-CoV-2?
生物光子学如何帮助牙科避免或最小化 SARS-CoV-2 的交叉感染?
Photodiagnosis Photodyn Ther. 2022 Mar;37:102682. doi: 10.1016/j.pdpdt.2021.102682. Epub 2021 Dec 12.
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Utility of Photodynamic Therapy in Dentistry: Current Concepts.光动力疗法在牙科中的应用:当前概念
Dent J (Basel). 2020 May 7;8(2):43. doi: 10.3390/dj8020043.