Faruk Mohammed, Ibrahim Sani, Adamu Ahmed, Rafindadi Abdulmumini Hassan, Ukwenya Yahaya, Iliyasu Yawale, Adamu Abdullahi, Aminu Surajo Mohammed, Shehu Mohammed Sani, Ameh Danladi Amodu, Mohammed Abdullahi, Ahmed Saad Aliyu, Idoko John, Ntekim Atara, Suleiman Aishatu Maude, Shah Khalid Zahir, Adoke Kasimu Umar
Department of Pathology, Ahmadu Bello University Faculty of Medicine, Zaria, Nigeria.
Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Intest Res. 2018 Jan;16(1):99-108. doi: 10.5217/ir.2018.16.1.99. Epub 2018 Jan 18.
BACKGROUND/AIMS: Colorectal cancer (CRC) is now a major public health problem with heavy morbidity and mortality in rural Africans despite the lingering dietary fiber-rich foodstuffs consumption. Studies have shown that increased intake of dietary fiber which contribute to low fecal pH and also influences the activity of intestinal microbiota, is associated with a lowered risk for CRC. However, whether or not the apparent high dietary fiber consumption by Africans do not longer protects against CRC risk is unknown. This study evaluated dietary fiber intake, fecal fiber components and pH levels in CRC patients.
Thirty-five subjects (CRC=21, control=14), mean age 45 years were recruited for the study. A truncated food frequency questionnaire and modified Goering and Van Soest procedures were used.
We found that all subjects consumed variety of dietary fiber-rich foodstuffs. There is slight preponderance in consumption of dietary fiber by the control group than the CRC patients. We also found a significant difference in the mean fecal neutral detergent fiber, acid detergent fiber, hemicellulose, cellulose and lignin contents from the CRC patients compared to the controls (<0.05). The CRC patients had significantly more fecal pH level than the matched apparently healthy controls (=0.017).
The identified differences in the fecal fiber components and stool pH levels between the 2 groups may relate to CRC incidence and mortality in rural Africans. There is crucial need for more hypothesis-driven research with adequate funding on the cumulative preventive role of dietary fiber-rich foodstuffs against colorectal cancer in rural Africans "today."
背景/目的：尽管非洲农村地区一直有富含膳食纤维的食物消费，但结直肠癌（CRC）如今仍是一个严重的公共卫生问题，发病率和死亡率都很高。研究表明，膳食纤维摄入量增加有助于降低粪便pH值，并影响肠道微生物群的活性，与结直肠癌风险降低有关。然而，非洲人明显较高的膳食纤维摄入量是否不再能预防结直肠癌风险尚不清楚。本研究评估了结直肠癌患者的膳食纤维摄入量、粪便纤维成分和pH值水平。
招募了35名受试者（结直肠癌患者=21名，对照组=14名），平均年龄45岁进行研究。使用了简化的食物频率问卷和改良的戈林和范索斯特方法。
我们发现所有受试者都食用了各种富含膳食纤维的食物。对照组的膳食纤维摄入量略高于结直肠癌患者。我们还发现，与对照组相比，结直肠癌患者粪便中的中性洗涤纤维、酸性洗涤纤维、半纤维素、纤维素和木质素含量的平均值存在显著差异（<0.05）。结直肠癌患者的粪便pH值水平显著高于匹配的明显健康对照组（=0.017）。
两组之间粪便纤维成分和粪便pH值水平的差异可能与非洲农村地区的结直肠癌发病率和死亡率有关。迫切需要更多有充分资金支持的、以假设为驱动的研究，来探讨如今富含膳食纤维的食物对非洲农村地区结直肠癌的累积预防作用。
