长链非编码RNA在生殖疾病中的调控作用
Regulatory role of long non-coding RNAs during reproductive disease.
作者信息
Liu Kangsheng, Mao Xiaodong, Chen Yajun, Li Taiping, Ton Hua
机构信息
Department of Clinical Laboratory, State Key Laboratory of Reproductive Medicine, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care HospitalNanjing 210029, Jiangsu, China.
Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineNanjing 210028, Jiangsu, China.
出版信息
Am J Transl Res. 2018 Jan 15;10(1):1-12. eCollection 2018.
Long non-coding RNA (lncRNA) is a group of RNAs with broad biogenesis, which are longer than 200 nt and highly conserved in their secondary and tertiary structures. lncRNA that broadly participates in varied physiological processes in organisms has abundant biological function and can regulate expression of target genes at transcriptional, post-transcriptional and epigenetic levels. LncRNAs can also affect the development of diseases, and therefore be used to diagnose and treat diseases. With new sequencing and microarray techniques, hundreds of lncRNAs involved in reproductive disorders have been identified, but their functions in these disorders are undefined. In this paper, we reviewed the studies on how lncRNAs participate in the development of reproductive disorders, hoping our outcome can instruct the future study and provide new biomarkers and therapies for reproductive disorders.
长链非编码RNA（lncRNA）是一类具有广泛生物合成的RNA，其长度超过200个核苷酸，二级和三级结构高度保守。广泛参与生物体各种生理过程的lncRNA具有丰富的生物学功能，可在转录、转录后和表观遗传水平上调控靶基因的表达。LncRNAs还可影响疾病的发展，因此可用于疾病的诊断和治疗。随着新的测序和微阵列技术的出现，已鉴定出数百种参与生殖障碍的lncRNAs，但其在这些障碍中的功能尚不清楚。在本文中，我们综述了关于lncRNAs如何参与生殖障碍发展的研究，希望我们的成果能够指导未来的研究，并为生殖障碍提供新的生物标志物和治疗方法。
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