Faraji Hossein, Paknahad Zamzam, Chitsaz Ahmad
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Department of Neurology, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Clin Nutr Res. 2018 Jan;7(1):40-47. doi: 10.7762/cnr.2018.7.1.40. Epub 2018 Jan 31.
The migraine headache is a disease related to the neurovascular system, which affects 10%-20% of people, worldwide. Recent evidences suggested a relation between thiamine status and migraine headaches. The current study was undertaken to assess dietary intake of the thiamine in migraine patients and to evaluate its association with the frequency of migraine attacks. In a case-control design, the current study was performed on 50 migraine patients and 50 healthy people, 20-60 years old in Isfahan, Iran, in 2017. Information about dietary intake was collected by Food frequency questionnaire and analyzed using the Nutritionist version 4 (N4) software (Tinuviel Software). Information about the history of disease was collected by demographic questionnaire. Analysis of covariance and independent t-test were used for data analysis and p value less than 0.05 was considered significant. Mean age, weight, height, and body mass index of participants were 35.1 ± 9.8 years, 65.3 ± 10.4 kg, 162.5 ± 8.4 cm, and 24.7 ± 4.0 kg/m, respectively. Dietary intake of thiamine among the migraine patients was lower than that in the healthy participants (p < 0.001). Migraine patients with the high frequency attacks had significantly lower intake of thiamine compared with moderate frequency attacks group (p = 0.010), however, it was not significant after adjusting for energy intake (p = 0.410, p = 0.240). Dietary intake of thiamine in migraine patients was not significantly different in comparing with healthy subjects. In addition, no significant correlation between thiamine intake and the frequency of migraine attacks was observed.
偏头痛是一种与神经血管系统相关的疾病，全球有10%-20%的人受其影响。最近的证据表明硫胺素状态与偏头痛之间存在关联。本研究旨在评估偏头痛患者硫胺素的饮食摄入量，并评估其与偏头痛发作频率的关联。在一项病例对照研究中，2017年在伊朗伊斯法罕对50名偏头痛患者和50名20-60岁的健康人进行了研究。通过食物频率问卷收集饮食摄入信息，并使用营养师4版（N4）软件（Tinuviel软件）进行分析。通过人口统计学问卷收集疾病史信息。采用协方差分析和独立t检验进行数据分析，p值小于0.05被认为具有统计学意义。参与者的平均年龄、体重、身高和体重指数分别为35.1±9.8岁、65.3±10.4千克、162.5±8.4厘米和24.7±4.0千克/米²。偏头痛患者的硫胺素饮食摄入量低于健康参与者（p<0.001）。与中度发作频率组相比，发作频率高的偏头痛患者硫胺素摄入量显著更低（p=0.010），然而，在调整能量摄入后差异无统计学意义（p=0.410，p=0.240）。偏头痛患者的硫胺素饮食摄入量与健康受试者相比无显著差异。此外，未观察到硫胺素摄入量与偏头痛发作频率之间存在显著相关性。
