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1
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.2018 年 IUPHAR/BPS 药理学指南：更新和扩展，以包含新的免疫药理学指南。
Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106. doi: 10.1093/nar/gkx1121.
2
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes.《药理学简明指南 2017/18：酶》
Br J Pharmacol. 2017 Dec;174 Suppl 1(Suppl Suppl 1):S272-S359. doi: 10.1111/bph.13877.
3
Warfarin related acute kidney injury: A case report.华法林相关性急性肾损伤：一例报告。
Indian J Nephrol. 2017 Jan-Feb;27(1):78-80. doi: 10.4103/0971-4065.177142.
4
Acenocoumarol: A Review of Anticoagulant Efficacy and Safety.醋硝香豆素：抗凝疗效与安全性综述
J Assoc Physicians India. 2016 Feb;64(2):88-93.
5
Anticoagulants and acute kidney injury: clinical and pathology considerations.抗凝剂与急性肾损伤：临床与病理相关因素。
Kidney Res Clin Pract. 2014 Dec;33(4):174-80. doi: 10.1016/j.krcp.2014.11.001. Epub 2014 Nov 18.
6
Warfarin related nephropathy: a case report and review of the literature.华法林相关性肾病：一例病例报告及文献综述
BMC Nephrol. 2016 Feb 1;17:15. doi: 10.1186/s12882-016-0228-4.
7
Anticoagulation-related nephropathy.抗凝相关肾病
J Thromb Haemost. 2016 Mar;14(3):461-7. doi: 10.1111/jth.13229. Epub 2016 Feb 15.
8
The occurrence of warfarin-related nephropathy and effects on renal and patient outcomes in korean patients.华法林相关性肾病的发生及其对韩国患者的肾脏和患者结局的影响。
PLoS One. 2013;8(4):e57661. doi: 10.1371/journal.pone.0057661. Epub 2013 Apr 1.
9
Acute kidney injury during warfarin therapy associated with obstructive tubular red blood cell casts: a report of 9 cases.华法林治疗期间与阻塞性肾小管红细胞管型相关的急性肾损伤：9例报告
Am J Kidney Dis. 2009 Dec;54(6):1121-6. doi: 10.1053/j.ajkd.2009.04.024. Epub 2009 Jul 4.

醋硝香豆素可作为华法林相关性肾病患者的替代抗凝剂。

Acenocoumarol as an alternative anticoagulant in a patient with warfarin-related nephropathy.

机构信息

Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Department of Cardiothoracic & Vascular Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

出版信息

Br J Clin Pharmacol. 2018 May;84(5):1068-1071. doi: 10.1111/bcp.13541. Epub 2018 Feb 28.

DOI:10.1111/bcp.13541
PMID:29424022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5903245/
Abstract

ADVERSE EVENT

Warfarin-related nephropathy.

DRUG IMPLICATED

Warfarin.

THE PATIENT

A 31-year-old female, managed with warfarin for rheumatic heart disease with atrial fibrillation.

EVIDENCE THAT LINKS THE DRUG TO THE EVENT

There were no alternative causes of nephropathy that could have caused the adverse event in this patient.

MANAGEMENT

Shifting the drug from warfarin to acenocoumarol.

MECHANISM

Difference in renal elimination between warfarin and acenocoumarol.

IMPLICATION FOR THERAPY

Clinicians should be aware of this rare adverse effect of warfarin, and acenocoumarol can be considered as an alternative therapy for this condition.

HYPOTHESES TO BE TESTED

Further prospectively designed studies are needed to consider acenocoumarol as an alternative therapy in warfarin-related nephropathy.

摘要

不良反应

华法林相关性肾病。

涉及药物

华法林。

患者

一名 31 岁女性，因风湿性心脏病伴心房颤动接受华法林治疗。

药物与事件关联的证据

无其他可能导致该患者发生不良反应的肾脏疾病病因。

处理方法

将药物从华法林转换为醋硝香豆素。

作用机制

华法林和醋硝香豆素在肾脏清除方面的差异。

治疗意义

临床医生应注意华法林这种罕见的不良反应，醋硝香豆素可作为这种情况下的替代治疗方法。

待检验假设

需要进一步前瞻性设计研究，以考虑在华法林相关性肾病中用醋硝香豆素替代治疗。