Vovkun Tatiana, Yanchuk Petro, Shtanova Lidiya, Veselskiy Stanislav, Filimonova Natalia, Shalamay Anatoly, Vedmid Volodymyr
Educational and Scientific Centre, Institute of Biology and Мedicine, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine. shtanova@ukr-net.
Gen Physiol Biophys. 2018 Jan;37(1):111-120. doi: 10.4149/gpb_2017015.
Water-soluble analogue of quercetin, corvitin is used in patients with myocardial infarction as blocker of 5-lipoxygenase. However, its effects on secretion, lipid content and physico-chemical properties of bile have not been understood yet. We investigated the effect of corvitin, applied in different doses, on the level of bile flow, the content of bile free and esterified cholesterol, phospholipids, triacylglycerols, and free fatty acids. In order to determine stability of the bile colloidal system, we examined the relationship between different lipid components. The rats were injected intraportally with a bolus of corvitin. At doses of 2.5, 5, and 10 mg/kg, the latter increased bile flow and concentration of total cholates, as well as free fatty acids. Corvitin (5 mg/kg) elevated phospholipids and cholesterol content, but at a dose of 10 mg/kg it increased the concentration of bile cholesterol esters and triacylglycerols. Corvitin applied at doses of 2.5 and 10 mg/kg increased total cholates/cholesterol ratio, but at a dose of 10 mg/kg, the drug reduced cholesterol / esterified cholesterol ratio. The results suggest that corvitin exerts choleretic effect and improves stability of bile colloidal system.
槲皮素的水溶性类似物柯维丁，在心肌梗死患者中用作5-脂氧合酶阻滞剂。然而，其对胆汁分泌、脂质含量和物理化学性质的影响尚不清楚。我们研究了不同剂量的柯维丁对胆汁流量、游离和酯化胆固醇、磷脂、三酰甘油和游离脂肪酸含量的影响。为了确定胆汁胶体系统的稳定性，我们研究了不同脂质成分之间的关系。通过门静脉给大鼠注射大剂量的柯维丁。在2.5、5和10mg/kg的剂量下，柯维丁增加了胆汁流量、总胆酸盐浓度以及游离脂肪酸含量。柯维丁（5mg/kg）提高了磷脂和胆固醇含量，但在10mg/kg的剂量下，它增加了胆汁胆固醇酯和三酰甘油的浓度。2.5和10mg/kg剂量的柯维丁增加了总胆酸盐/胆固醇比率，但在10mg/kg的剂量下，该药物降低了胆固醇/酯化胆固醇比率。结果表明，柯维丁具有利胆作用，并改善了胆汁胶体系统的稳定性。
