Boyle A G, Timoney J F, Newton J R, Hines M T, Waller A S, Buchanan B R
University of Pennsylvania, New Bolton Center, Kennett Square, PA.
University of Kentucky, Gluck Research Center, Lexington, KY.
J Vet Intern Med. 2018 Mar;32(2):633-647. doi: 10.1111/jvim.15043. Epub 2018 Feb 9.
This consensus statement update reflects our current published knowledge and opinion about clinical signs, pathogenesis, epidemiology, treatment, complications, and control of strangles. This updated statement emphasizes varying presentations in the context of existing underlying immunity and carrier states of strangles in the transmission of disease. The statement redefines the "gold standard" for detection of possible infection and reviews the new technologies available in polymerase chain reaction diagnosis and serology and their use in outbreak control and prevention. We reiterate the importance of judicious use of antibiotics in horses with strangles. This updated consensus statement reviews current vaccine technology and the importance of linking vaccination with currently advocated disease control and prevention programs to facilitate the eradication of endemic infections while safely maintaining herd immunity. Differentiation between immune responses to primary and repeated exposure of subclinically infected animals and responses induced by vaccination is also addressed.
本共识声明更新内容反映了我们目前已发表的关于马腺疫的临床体征、发病机制、流行病学、治疗、并发症及防控方面的知识和观点。这份更新后的声明强调了在现有基础免疫力及马腺疫带菌状态背景下，疾病传播过程中出现的不同表现形式。声明重新定义了检测可能感染的“金标准”，并回顾了聚合酶链反应诊断和血清学方面可用的新技术及其在疫情控制和预防中的应用。我们重申对患马腺疫马匹谨慎使用抗生素的重要性。这份更新后的共识声明回顾了当前的疫苗技术，以及将疫苗接种与当前倡导的疾病控制和预防计划相结合的重要性，以便在安全维持畜群免疫力的同时促进地方流行性感染的根除。文中还讨论了亚临床感染动物初次和再次接触后的免疫反应与疫苗接种诱导的免疫反应之间的差异。
