Department of Microbiology and Immunology, Miami Center for AIDS Research.
Division of Infectious Disease.
AIDS. 2018 Jun 1;32(9):1085-1094. doi: 10.1097/QAD.0000000000001774.
To determine influence of age and HIV infection on influenza vaccine responses.
Evaluate serologic response to seasonal trivalent influenza vaccine (TIV) as the immunologic outcome in HIV-infected (HIV⁺) and age-matched HIV negative (HIV⁻) adults.
During 2013-2016, 151 virologically controlled HIV⁺ individuals on antiretroviral therapy and 164 HIV⁻ volunteers grouped by age as young (<40 years), middle aged (40-59 years) and old (≥60 years) were administered TIV and investigated for serum antibody response to vaccine antigens.
At prevaccination (T0) titers were in seroprotective range in more than 90% of participants. Antibody titers increased in all participants postvaccination but frequency of classified vaccine responders to individual or all three vaccine antigens at 3-4 weeks was higher in HIV⁻ than HIV⁺ adults with the greatest differences manifesting in the young age group. Of the three vaccine strains in TIV, antibody responses at T2 were weakest against H3N2 with those to H1N1 and B antigens dominating. Among the age groups, the titers for H1N1 and B were lowest in old age, with evidence of an age-associated interaction in HIV⁺ persons with antibody to B antigen.
Greater frequencies of vaccine nonresponders are seen in HIV⁺ young compared with HIV⁻ adults and the observed age-associated interaction for B antigen in HIV⁺ persons are supportive of the concept of premature immune senescence in controlled HIV infection. High-potency influenza vaccination recommended for healthy aging could be considered for HIV⁺ adults of all ages.
确定年龄和 HIV 感染对流感疫苗反应的影响。
评估 HIV 感染（HIV⁺）和年龄匹配的 HIV 阴性（HIV⁻）成年人对季节性三价流感疫苗（TIV）的血清学反应作为免疫结果。
在 2013 年至 2016 年期间，151 名接受抗逆转录病毒治疗的病毒学控制良好的 HIV⁺个体和 164 名按年龄分组的 HIV⁻志愿者（分为年轻组<40 岁）、中年组（40-59 岁）和老年组（≥60 岁）接种了 TIV，并调查了他们对疫苗抗原的血清抗体反应。
在接种前（T0），超过 90%的参与者的抗体滴度处于保护范围内。所有参与者在接种后抗体滴度均增加，但在 3-4 周时，对个体或所有三种疫苗抗原的分类疫苗应答者的频率在 HIV⁻成年人中高于 HIV⁺成年人，差异最大的是在年轻组。在 TIV 的三种疫苗株中，H3N2 的抗体反应在 T2 时最弱，H1N1 和 B 抗原的抗体反应最强。在年龄组中，H1N1 和 B 的滴度在老年组中最低，在 HIV⁺人群中存在 B 抗原的与年龄相关的相互作用，支持在控制的 HIV 感染中存在免疫衰老提前的概念。对于所有年龄的 HIV⁺成年人，推荐使用高效流感疫苗来实现健康老龄化。
