Laboratory of Tumor Heterogeneity and Stemness in Cancer, ISREC (Swiss Institute for Experimental Cancer Research), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Laboratory of Translational Oncology, ISREC (Swiss Institute for Experimental Cancer Research), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Cell. 2018 Feb 8;172(4):643-644. doi: 10.1016/j.cell.2018.01.028.
While functional heterogeneity of fibroblastic cells populating the tumor microenvironment is increasingly recognized, lack of definitive markers complicates elucidation of roles among ostensibly distinctive fibroblastic states. In this issue of Cell, Su et al. characterize a new pro-tumorigenic cancer-associated fibroblast subset mediating chemoresistance defined and driven by a novel signaling pathway.
虽然越来越多的人认识到填充肿瘤微环境的成纤维细胞的功能异质性，但由于缺乏明确的标志物，阐明明显不同的成纤维细胞状态之间的作用变得复杂。在本期《细胞》杂志中，Su 等人描述了一个新的促肿瘤发生的癌相关成纤维细胞亚群，该亚群通过一条新的信号通路被定义和驱动，介导化疗耐药性。
