Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Int J Biol Macromol. 2018 Jun;112:862-867. doi: 10.1016/j.ijbiomac.2018.01.214. Epub 2018 Feb 7.
Sanguisorba officinalis L. is widely used in China to treat various wounds, particularly burns. The present study was carried to evaluate the healing efficacy of a purified polysaccharide (SOP) from the roots of S. officinalis L. on burn wound models in mice. The results indicated that oral administration of SOP (50 and 200mg/kg) significantly stimulated wound contraction and reduced epithelialization time as compared to control group, which might be mediated by promoting collagen synthesis as evidenced by an increase of hydroxyproline content. Elevation of IL-1β and VEGF content was also observed in mice following SOP treatment, which in turn facilitate epithelization and angiogenesis. Besides, histopathological examination of the wound tissues in the SOP-treated animals showed collagen deposition and epidermal formation. It may be concluded that the enhancement of burn wound healing by SOP might be due to promotional collagen synthesis and angiogenesis during skin wound repair as a result of the stimulation of hydroxyproline, IL-1β and VEGF production. The excellent wound-healing activities of SOP provide a scientific rationale for the development of plant-based product in the management of wounds.
地榆（Sanguisorba officinalis L.）在中国被广泛用于治疗各种伤口，特别是烧伤。本研究旨在评估地榆根中纯化多糖（SOP）对小鼠烧伤模型的愈合效果。结果表明，与对照组相比，SOP（50 和 200mg/kg）的口服给药显著刺激了伤口收缩并减少了上皮化时间，这可能是通过增加羟脯氨酸含量促进胶原蛋白合成介导的。SOP 处理后小鼠的 IL-1β 和 VEGF 含量也升高，这反过来又促进了上皮形成和血管生成。此外，SOP 处理动物的伤口组织的组织病理学检查显示胶原蛋白沉积和表皮形成。可以得出结论，SOP 通过促进胶原蛋白合成和血管生成来增强烧伤伤口愈合，这是由于羟脯氨酸、IL-1β 和 VEGF 产生的刺激作用。SOP 的优异伤口愈合活性为基于植物的产品在伤口管理中的开发提供了科学依据。
