Yeoh E K, Lai C L, Chang W K, Lo H Y
J Hyg (Lond). 1986 Jun;96(3):491-9. doi: 10.1017/s0022172400066298.
Four thousand and one hospital staff were screened for hepatitis B virus (HBV) markers in a vaccination programme in Hong Kong. The seropositivity rate for HBsAg, anti-HBs and anti-HBc were significantly higher in the 3160 existing hospital staff than in 841 new recruits. Of the subjects negative for HBV markers, 605 were randomized to receive three doses of either 10 or 20 micrograms of the Merck Institute vaccine (HB-VAX). Compared with the 20 micrograms dose, vaccination with the 10 micrograms dose results in equal immunogenicity and efficacy at the completion of the three injections but induced a slower response rate and lower anti-HBs titres with the first two doses. The commonest side-effect of local soreness was less with the 10 micrograms dose. We conclude that (1) hospital staff working in high endemic areas should be vaccinated on recruitment and (2) the 10 micrograms dose of HB-VAX can replace the recommended 20 micrograms dose for adults, being cheaper and as efficacious.
在香港的一项疫苗接种计划中，对4001名医院工作人员进行了乙肝病毒（HBV）标志物筛查。3160名在职医院工作人员的HBsAg、抗-HBs和抗-HBc血清阳性率显著高于841名新入职人员。在HBV标志物呈阴性的受试者中，605人被随机分为两组，分别接种3剂10微克或20微克的默克研究所疫苗（HB-VAX）。与20微克剂量相比，10微克剂量的疫苗在完成3次注射后具有相同的免疫原性和效力，但在前两剂注射时诱导的反应率较慢，抗-HBs滴度较低。10微克剂量的疫苗最常见的局部疼痛副作用较少。我们得出结论：（1）在高流行地区工作的医院工作人员应在入职时接种疫苗；（2）10微克剂量的HB-VAX可以替代推荐的20微克成人剂量，价格更便宜且效果相同。
