Chen Yunbing, Zhou Ziyu, Chen Yanxi, Chen Di
Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
State Key Laboratory of Biobased Transportation Fuel Technology, Haining, Zhejiang, 314400, China.
Cell Biosci. 2024 Sep 28;14(1):124. doi: 10.1186/s13578-024-01293-7.
N-methyladenosine (mA) represents the most prevalent internal and reversible modification on RNAs. Different cell types display their unique mA profiles, which are determined by the functions of mA writers and erasers. MA modifications lead to different outcomes such as decay, stabilization, or transport of the RNAs. The mA-encoded epigenetic information is interpreted by mA readers and their interacting proteins. MA readers are essential for different biological processes, and the defects in mA readers have been discovered in diverse diseases. Here, we review the latest advances in the roles of mA readers in development and diseases. These recent studies not only highlight the importance of mA readers in regulating cell fate transitions, but also point to the potential application of drugs targeting mA readers in diseases.
N6-甲基腺苷（m6A）是RNA上最普遍的内部可逆修饰。不同细胞类型呈现出其独特的m6A图谱，这由m6A写入器和擦除器的功能所决定。m6A修饰会导致RNA出现诸如降解、稳定或转运等不同结果。m6A编码的表观遗传信息由m6A读取器及其相互作用蛋白进行解读。m6A读取器对不同生物学过程至关重要，并且在多种疾病中已发现m6A读取器存在缺陷。在此，我们综述m6A读取器在发育和疾病中作用的最新进展。这些最新研究不仅突出了m6A读取器在调节细胞命运转变中的重要性，还指出了靶向m6A读取器的药物在疾病中的潜在应用。
