Northeast Agricultural University, School of Life Science, Harbin, Heilongjiang Province, China.
Life Science and Biotechnique Research Center, A Division of Northeast Agricultural University, Harbin, Heilongjiang Province, 150030, China.
Inflammation. 2018 Jun;41(3):751-759. doi: 10.1007/s10753-018-0729-3.
Fibroblast growth factor 21 (FGF-21) has been previously judged as a major metabolic regulator. In this paper, we show that FGF-21 has a potential role in anti-inflammation and immunoregulation. In vivo, treatment with exogenous FGF-21 can alleviate LPS-induced inflammation. In vitro, FGF-21 inhibited LPS-induced IL-1β expression in THP-1 cells. Furthermore, besides the NF-κB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway. This study clearly indicates that FGF21 can be used as an attractive target for the management of inflammatory disorders. This piece of research indicates that FGF-21 could have much value in the management of inflammatory disorders.
成纤维细胞生长因子 21（FGF-21）先前被认为是一种主要的代谢调节剂。在本文中，我们表明 FGF-21 在抗炎和免疫调节方面具有潜在作用。在体内，外源性 FGF-21 的治疗可以减轻 LPS 诱导的炎症。在体外，FGF-21 抑制了 THP-1 细胞中 LPS 诱导的 IL-1β 表达。此外，除了 NF-κB 途径外，还观察到 FGF-21 的作用机制涉及 ERK1/2 途径中 IL-10 的升高。这项研究清楚地表明，FGF21 可用作治疗炎症性疾病的有吸引力的靶标。这项研究表明，FGF-21 在炎症性疾病的治疗中可能具有很高的价值。
