Department of Restorative Dentistry and Periodontology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand.
Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
BMC Oral Health. 2022 Dec 6;22(1):570. doi: 10.1186/s12903-022-02533-3.
Fibroblast growth factor 21 (FGF21) is closely associated with metabolic syndrome (MetS). An alteration of FGF21 is possibly affected by periodontitis. The present study aimed to investigate the levels of serum FGF21 in MetS patients with generalized periodontitis and its association with periodontal and metabolic parameters.
One hundred forty-six MetS patients were recruited from the CORE (Cohort Of patients at a high Risk for Cardiovascular Events) Thailand registry. All participants received general data interviewing, periodontal examination and blood collection for measurement of FGF21 levels and biochemistry parameters. Periodontitis was defined according to the new classification and divided into two groups of localized periodontitis and generalized periodontitis.
FGF21 was significantly higher in generalized periodontitis group when compared with localized periodontitis group (p < 0.05). The significant correlation was observed between FGF21 and variables including number of remaining teeth, mean clinical attachment loss, hypertriglyceridemia and low high-density lipoprotein cholesterol. The elevation of serum FGF21 was associated with presence of generalized periodontitis after adjusting of covariate factors (OR = 27.12, p = 0.012).
The elevation of serum FGF21 might be a potential biomarker for MetS patients who have risk of generalized periodontitis.
成纤维细胞生长因子 21（FGF21）与代谢综合征（MetS）密切相关。FGF21 的改变可能受到牙周炎的影响。本研究旨在探讨代谢综合征伴广泛牙周炎患者血清 FGF21 水平及其与牙周和代谢参数的关系。
从泰国 CORE（心血管事件高危患者队列）登记处招募了 146 名代谢综合征患者。所有参与者均接受了一般数据访谈、牙周检查和血液采集，以测量 FGF21 水平和生化参数。根据新的分类，将牙周炎分为局限性牙周炎和广泛性牙周炎两组。
与局限性牙周炎组相比，广泛性牙周炎组的 FGF21 显著升高（p<0.05）。FGF21 与包括剩余牙齿数量、平均临床附着丧失、高三酰甘油血症和低高密度脂蛋白胆固醇在内的变量之间存在显著相关性。在校正了协变量因素后，血清 FGF21 升高与广泛性牙周炎的存在相关（OR=27.12，p=0.012）。
血清 FGF21 升高可能是代谢综合征患者发生广泛性牙周炎风险的潜在生物标志物。
