Divison of Respiratory Medicine, Department of Pediatrics and Translational Medicine, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Department of Medicine, McMaster University, Hamilton, Canada.
Semin Respir Crit Care Med. 2018 Feb;39(1):3-11. doi: 10.1055/s-0037-1618568. Epub 2018 Feb 10.
Asthma is a heterogeneous disorder with a complex etiology. Prevalence rates for asthma have been increasing in many countries over the past few decades. While it is unclear why this increase is occurring, the variation reported in asthma prevalence and severity associated with ethnicity offers some insight into the determinants of asthma. In this chapter, we discuss the data linking asthma to ethnicity and some of the factors that may explain this association. These include socioeconomic status, environmental exposures, the host microbiome, and genetics. A better understanding of these processes may inform future mechanistic studies and identify modifiable risk factors for targeted health care interventions.
哮喘是一种具有复杂病因的异质性疾病。在过去几十年中,许多国家的哮喘患病率一直在上升。虽然尚不清楚为什么会出现这种增加,但与种族有关的哮喘患病率和严重程度的差异为哮喘的决定因素提供了一些见解。在本章中,我们讨论了将哮喘与种族联系起来的数据,以及可能解释这种关联的一些因素。这些因素包括社会经济地位、环境暴露、宿主微生物组和遗传学。更好地了解这些过程可能会为未来的机制研究提供信息,并确定可改变的风险因素,以进行有针对性的医疗保健干预。