Howard University Cancer Center, Howard University, Washington, DC, United States.
Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States.
Contemp Clin Trials. 2018 Apr;67:121-128. doi: 10.1016/j.cct.2018.02.005. Epub 2018 Feb 8.
African-American women (AAW) are more likely to be metabolically unhealthy than White women (WW). Metabolic syndrome (MetS) is associated with increased breast cancer risk and mortality from breast cancer is greater in AAW compared to WW. Data show MetS affects health-related quality of life (HRQoL). Exercise studies report improvements in MetS, however, no study to date has examined HRQoL in metabolically unhealthy AAW enrolled in an exercise trial.
This report examined the effect of a 6-month, 3-arm (supervised exercise, home-based exercise, control) randomized exercise controlled trial on HRQoL among 213 obese, metabolically unhealthy, postmenopausal AAW at high risk for breast cancer.
Certain baseline participant characteristics were related to baseline HRQoL dimensions. The "exercise group" (supervised group combined with the home-based group) showed significantly greater improvement in health change scores (M = 13.6, SD = 3.1) compared to the control group (M = 0.7, SD = 4.4) (p = 0.02) over the 6-month study period. There were no significant differences in HRQoL change scores between the 3 study groups, however, although non-significant, data indicated most HRQoL change scores were more favorable in the supervised group.
While significant improvement occurred in health change scores in the combined supervised and home-based group compared to the control group, we did not observe any significant differences on HRQoL change scores between all three study groups. However, while non-significant, there was a trend for more favorable HRQoL change scores in the supervised group versus the home-based and control groups. Additional research is needed to further explore this topic.
非裔美国女性（AAW）比白人女性（WW）更容易出现代谢不健康的情况。代谢综合征（MetS）与乳腺癌风险增加有关，并且 AAW 死于乳腺癌的风险高于 WW。数据表明代谢综合征会影响健康相关生活质量（HRQoL）。运动研究报告称代谢综合征得到了改善，然而，迄今为止，没有研究检查过参加运动试验的代谢不健康的 AAW 的 HRQoL。
本报告检查了 6 个月 3 臂（监督运动、家庭运动、对照组）随机运动对照试验对 213 名肥胖、代谢不健康、绝经后、有乳腺癌高风险的 AAW 的 HRQoL 的影响。
某些基线参与者特征与基线 HRQoL 维度有关。与对照组（M=0.7，SD=4.4）（p=0.02）相比，“运动组”（监督组与家庭组结合）在 6 个月的研究期间，健康变化评分（M=13.6，SD=3.1）显著提高。3 个研究组之间的 HRQoL 变化评分没有显著差异，但是，尽管没有统计学意义，但数据表明，监督组的大多数 HRQoL 变化评分更有利。
虽然与对照组相比，联合监督和家庭运动组的健康变化评分显著提高，但我们没有观察到所有三个研究组之间的 HRQoL 变化评分有任何显著差异。然而，尽管没有统计学意义，但监督组的 HRQoL 变化评分更有利，与家庭组和对照组相比，有一个趋势。需要进一步研究来进一步探讨这个问题。
