Public Health, Department of Social Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan; Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt.
Public Health, Department of Social Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan.
Nutrition. 2018 Mar;47:50-55. doi: 10.1016/j.nut.2017.09.009. Epub 2017 Oct 12.
A few reports have investigated the association of dietary vitamin intakes with risk of heart failure in Asia. Therefore, we examined the relation between dietary intakes of fat-soluble vitamins A, K, E, and D and mortality from heart failure in the Japanese population.
A total of 23 099 men and 35 597 women ages 40 to 79 y participated in the Japan Collaborative Cohort Study and completed a food frequency questionnaire from which dietary intakes of vitamins A, K, E, and D were calculated. The Cox proportional hazard model was used to estimate the sex-specific risks of heart failure mortality according to increasing quintiles of fat-soluble vitamin intakes.
During the median 19.3 y follow-up period, there were 567 deaths from heart failure (240 men, 327 women). Dietary vitamin A intake showed no association with heart failure mortality in both sexes; however, the reduced risk was observed in women but not in men with dietary intakes of vitamins K, E, and D. The multivariable hazard ratios (95% confidence interval) in the highest versus the lowest intake quintiles among women were 0.63 (0.45-0.87; P for trend = 0.006) for vitamin K, 0.55 (0.36-0.78; P for trend = 0.006) for vitamin E, and 0.66 (0.48-0.93; P for trend = 0.01) for vitamin D. The association for each vitamin was slightly attenuated but remained statistically significant after mutual adjustment for intakes of the other vitamins.
High dietary intakes of fat-soluble vitamins K, E, and D were associated with a reduced risk of heart failure mortality in Japanese women but not men.
有一些报告研究了膳食维生素摄入量与亚洲心力衰竭风险之间的关系。因此，我们研究了日本人群中脂溶性维生素 A、K、E 和 D 的膳食摄入量与心力衰竭死亡率之间的关系。
共有 23099 名男性和 35597 名年龄在 40 至 79 岁的女性参加了日本合作队列研究，并完成了一份食物频率问卷，从中计算出维生素 A、K、E 和 D 的膳食摄入量。使用 Cox 比例风险模型根据脂溶性维生素摄入量递增五分位数，估计男女心力衰竭死亡率的特定性别风险。
在中位 19.3 年的随访期间，共有 567 人死于心力衰竭（240 名男性，327 名女性）。在两性中，维生素 A 摄入量与心力衰竭死亡率均无关联；然而，在女性中观察到风险降低，但在男性中则没有。女性中最高与最低摄入量五分位数的多变量风险比（95%置信区间）分别为维生素 K 为 0.63（0.45-0.87；趋势 P 值=0.006）、维生素 E 为 0.55（0.36-0.78；趋势 P 值=0.006）和维生素 D 为 0.66（0.48-0.93；趋势 P 值=0.01）。在相互调整其他维生素的摄入量后，每种维生素的关联略有减弱，但仍具有统计学意义。
日本女性中，高膳食脂溶性维生素 K、E 和 D 摄入量与心力衰竭死亡率降低相关，但在男性中则无此关联。
